| PrefaceThe association of hypertension and obesity is well recognized. Hypertension is common and powerful contributor to cardiovascular diseases including coronary heart disease, stroke. Obesity greatly increases the risks of developing these diseases. However, the nature of relationship between hypertension and obesity has still remained obscure. Blood pressure is associated with race, gender, lifestyle and various factors. Lifestyle has remarkably changed in China. Several studies have already revealed its associations between Chinese and Japanese. We are ongoing the co - operative research of hypertension and cardiovascular diseases in Shenyang and Tokyo. Our aim of this study is to compared the prevalence of hypertensive obese patients, o-besity - related factors with hypertensive subjects and its treatments between Shenyang and Tokyo.Subjects and MethodsTwo hundreds consecutive cases with hypertension were examined at the respective outpatients units of China Medical University hospital in Shenyang and Ziwei medical university hospital in Tokyo were selected respectively between May 2001 and December 2001. Anthropometries measures included body mass index ( BMI) as measure of body build is derived from body weight and height. Each patient was hypertensive with>l40mmHg in systolic pressure and/or >90 mmHgin diastolic pressure or receiving antihypertensive drug. Obesity is defined as over 25 in BMI and non - obese is as less than 22.9. Blood pressure was measured by mercury sphyngmanometer and measurements were repeated two times or more. Physicians administered the research sheet including items of anthropometries measures, blood chemistry, electrocardiography, ultrasound echocardiography and questionnaire of personal lifestyle. A structure questionnaire was used for face - to - face interview including items of demographic data, medical history, lifestyle and treatments. Blood samples were analyzed in laboratory centers of each hospital. Level units of serum chemistry is used mmol/1 in Shenyang and mg/dl in Tokyo, so all u-nits were unified as mg/dl in present study.Statistical analyses were performed by unpaired Student's t - test, chi square test for category data, and the correlation between two continuous variables was assessed by Spearman's correlation method ( Stat-View. ver 4.5J,Abacus Concept, Berkeley, CA,USA). Values were expressed as mean SD, and two - tailed P values less than 0.05 were considered to statistical significance.Results1. Both men and women in Shenyang had significantly lower age of hypertension than that of men and women in Tokyo ( p < 0. 001). The distribution of obese hypertensive ( BMI > 25 ) was 49 cases (44%) men, 22 (25%) women in Shenyang, and was 23 cases (20%) men, 11 {13%) women in Tokyo respectively. The prevalence of obese men and women hypertensive patients in Shenyang was significantly higher than in Tokyo (men: p <0. 001, women; p <0.05).2. Systolic blood pressure (SBP) and diastolic blood pressure ( DBF) of obese males patients were higher than those of non ?obese males (BMI^22.9) (p <0.05,respectively). DBF of obese females was higher than of non - obese females in Shenyang ( p <0.05) . SBP and DBF of obese males were higher than those of normal BMI males in Tokyo (p<0.01,p<0. 05 respectively). DBP of obese females were significantly higher than that of non - obese females in Tokyo ( p< 0.05 ). The association between hypertension and BMI in male was stronger than that of female was.3. In male cases of Shenyang, total cholesterol ( TC) , triglycer-ide (TG) and fasten plasma glucose ( FPG) of obesity were significantly higher and HDL cholesterol ( HDL - c ) was lower than those of non-obese patients (TC: p < 0. 05, TG: p< 0,001, FPG:p<0. 001, HDL - c: p < 0.01, respectively). In female, there was not significant difference of all these items between obesity and non - obesity group. In Tokyo, TC^TG and FPG of male obesity group were significantly higher and HDL - c of obese was lower than those of non -obese group (TC: p<0.05... |
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