| ABSTRACTPAR I: 1MPROVED QUALITY-OF-LIFE OF MEDIUM OR LATESTAGE LIVER CANCER PATIENTS BY CURCUMA AROMATICAOIL (CAO) INTERWNT1ONALTHERAPYObjectivc: To study recent therapeutic effects of CAO interventonal therapfOr medium or late stage of PLC as well as Quality-of life(QOL) ialluence ofPrimary Liver Cancer (PLC) patients compared with transcatheter ederialchemoembolization (TACE).Method:70 PLC cases (41 patients) of medium or late Stage were edmlydivided into CAO grouP (n==36) and TACE grouP(n=34).The CAO grouP wertreated with CAO or CAO+Lip iboonal theraPy While the TACE grouPwere treated with cheInotheraPelltics or chemotheraPeutcs+Lip interventionaltheraPy. The points of QOL wee respectvely measured l-3 days before and 2weeks after interventional theraPy according to "Quality of life Scale forpatiellts of liver cancer .. QOL, AFP, liver fullotion, lddney function,hematoPOietic function of marrow and cruor fimction were observed andcomPared.Results: The effective ratCs of the CAO grouP and the TACE grouP arerespeCtively o% and l4.7l%, and the StCady ndes are resPectively l00% and85.29%. There is no statistical diffeence between the two grouPs re=0.054l).The alterationS of AFP,ALP, Y -GT,TBIL and RBC are no statisticaldifference bforeen the tWo grouPs after the tfeatInent, While the alterations ofALT, AST, WBC, PLT, PT, FIB, Cr and BuN of TACE grOuP are grCater thanthe CAO grouP(P<0.05). According to Binny Logistic Regression, Whichhave positive relation with imProved QOL more than 5% are the Kamofskypoinis, the totai QOL poinis, Y -GT, WBC, RBC, PLT and Cr beforetrCdriellt, Y -GT, WBC, RBC, PLT, and Cr after tretheellt: Which havenegative relation are: AFP, ALT, AST, ALP, rsIL, PT, FIB and BuN beforetrCthellt, the total poinis of QOL, AFP, ALT, AST, ALP, TBIL, PT, FIB andBuN after trCtheent.ConcIusion: CAO has good antinoplastic effects. The recent therapeoticeffects of CAO interVenona therapy Wth PLC are similar to TACE. CAOdoes less lesion to liver function, lddney fhaction, hematpoietic function ofmarrow and cruor funCtion, and is safer than TACE. The probable mechanismsof CAO imPrving QOL of PLC pati0lls are the anineoplastic effeets and less6side-effect tO orgbosm of CAO.Kepoords: Cureuma Aromatica Oil(CAO), InterVentional TheraPy, PrimaryLiver Cancer(PLC), Quality of lif0(QOL)PART ll: THE OBSERVAION OF THERAPEUTIC EFFECTS ANDhoYSES OF PsoGNOSIS FACTOas FOR THECOMPREHENSIVE TasATMwiT OF MEDIUM OR LATE STAGEOF LIrsRCANCcaObjeCtive:TO observe and comPare the thprapeutic effects of thecHsive trCbe of Meditnn-stage or late-Stage PLC, and analyse theprognO5is hars.MethOds: 322 PLC cases of mediwn or late stage treated by MedicaiDePartInent of oncology of Traditional Chinese Medical HosPital ofGUangdon Provipoe were rthespectivly researched. It 6theraPeutic faCtors: TACE, TAI, chemotheraPy, Traditionsl Chinese Medicine(TCM) intervene embolism and the diaieGtical Of TCM. The cumulativeProportion sUrViving of each theraPeutic factOr was analysed by theKaPlan-Meier statistical method. 25 prognosis factors were selected, and wereanalysed by the cox regression method. Then doperous factors and protCctivefaCtors were screened out, which may offer referece for clinical trCtheent ofPLC in the for.Result: 0.5 and 1 yCar cumulative PropOrtion surviving were rased by thedialecticaltreaAnentofTCM (87.76% vs 45.25%, 42.l2% vs 2.39%,P<0.05 ), TACE (89.33 % vs 80.95%, 64.09 % vs 0.3l%, P<0.05 ), and TCMintervene embolism (95.43 % vs 55.90%, 57.l4% vs 3l.52%, P<0.05 ), butnduced byTAI (55.56% vs 89.76%, l8.43% vs44.08%, P<0.05) andchemotheraP (70.59% vs 84.28%, 0% vs43.27%, P<0.05).25 prognosis faCtrs were analysed by the cox regression method, theresult shows: the dialectical tyPe TCM, tUmour focus number,theour enveloPe,AFP level in serum, the Child's ghe of 1iver boion, ascites, foranembois and lnttwe emboIism effect the curnulative Prop... |
PDF Full Text Request