Compound Danshen Injection To Prevent The Initial Study Of Femoral Head Necrosis

Radix Salviae Miltiorrhizaepreventing the steroidinduced avsacular necrosis of femoral headSpeciality: OrthopaedicsStudent:Shi Feng LeiTutor: Prof. Shao Guang XiangABSTRACTObjective:To observe the effects of Radix Salviae Miltiorrhizae preventing the steroid induced avsacular necrosis of femoral head. And to investigate the internal mechanism. Methods: Osteonecrosis of the femoral head was induced experimentaliy in chickens after the administration of a high dose of Prednisolone . R. S. Mwas used to prevent the effects of steroid induced osteonecrosis of the femoral head . 30adult chickens we used: 14 received prednisolone 5mg/kg, twice a week via intramuscular injection (Group A) - Ten received the steroid (as in Group A) plus R.S.m 0.5 rd/kg 5 times a week via intra muscular injection(Group B). another 6 received no medication and served as the control group (Group C). To observe the changes on hemorheology~. fat metabolism and femoral heads. Results:Evidence of osteoneerosis was observed in specimens from Group A, induding subchondral bone death and fat cell proliferation. Conversely, sections from Group B showed less adipogenesis and no bone death. It is concluded that pharrnacon which invigorate the circulation of blood, such as R. S. M may be helpful in preventing the steroid induced osteonecrosis, by regulating the fat transfer in thd body and promote the micro ?circulation of the femoral head.