Durogesic For Postoperative Analgesia Of The Upper Abdomen

1 .Background Durogesic, also called transdermal fentanly, is the first available opioid- like drug to be delivered by the way of transderm. It is reported that durogesic can decrease the dose of opioid for the postoperative pain and has a better analgesic effect. The study is to evaluate the effect and safety of durogesic for postoperative pain in patients undergoing upper abdominal surgery. 2.Materials and Methods Twenty seven patients undergoing elective upper abdominal surgery were randomly entered into two groups,durogesic group (group D, 13 Gases) and placebo group (group C,14 cases) . Forty five mm before the operation two patchs of durogesic each rated to deliver fentanyl at 25 11 g/h were applied to the subclavian skin and worn for 24 hours in group D, and two patches without drugs were used in group C. All patients experienced general anesthesia with propofol, fentanyl, isoflurane, and vecuronium. As soon as the operations ended, all patients were transferred to the PACU. After extubation, the patient-controlled analgesia pumps were used if patients complained of pain. All patients were monitored ECG, R.R, Sp02, NBP for 44h and the administered dosage of morphine and VAS were recorded every 4h. 3.Results The group D demanded significantly less morphine than the group C after 8h; The VAS of group D was significantly lower than that of group C during the whole monitoring period; The evidence of respiratory depression was not found in any patients; There was no difference between two groups in the incidence of adverse effects such as nausea, vomiting, urinary retention, prurltus. 4.Conclusion Durogesic(Transdermal fentanly) may be useful in the treatment of pain after surgery if proper dosage and proper method were selected.