Positioning Expression Of Timp-1 And Laminin In Prostate Cancer And Its Clinical Significance

Objective To study TIMP-1 and laminin(LN) expression in prostate carcinoma and to evaluate its clinical significance. Materials and methods expression of TIMP- 1 and LN were studied by inununohistcchemical technique (S-P method) in formalin-fixed paraffin rnbeded. specimens of 43 prostate cancer tissues and 10 benign prostatic hyperplasia (BPH) tissues, their clinical significance was analysed. Results The TIMP-1 expression in prostate cancer tissues was lower than in BPH tissues (p<0.Ol) There were significant inverse correlations between the TIMP-1 expression and clinical stage (P<0.01), patholo- gical differentiation (p