Cerebral Infarction On Serum, Red Blood Cell And Platelet Magnesium Levels And Platelet Activation Degree

Objective To investigate the correlation of magnesium, platelet activation and cerebral infaction and effect of magnesium on platelet activation. Methods Using flame atomic absorption spectrophotometry and radioimmunoassay, the levels of serum magnesium, erythrocytes magnesium, platelets magnesium and platelet activation were determined in 30 cases of acute cerebral infarction (ACI) and 25 cases of normal controls(NC) (P<0.01).Results The levels of serum magnesium, erythrocytes magnesium and platelet magnesium in patients with ACI was all lower than those in NC.The number of GMP-140 molecules on platelet surface in patients with ACI was higher than that in NC (P<0.05). We found that the level of serum magnesium was positively correlative to the level of eruthrocytes magnesium and it changed as the same as the level of platelet magnesium. But the levels of serum magnesium and platelets magnesium were negatively correlative to the number of GMP-140 molecules on platelet surface respectively. Conclusion The results suggest that the level of magnesium is decreased and the level of platelet activation is increased in patients with ACI. The enhancement of the degree of platelet activation is possibly related to the reduction of serum magnesium and platelets magnesium. It indicates that the supplement of magnesium might be useful clinically to acute cerebral infarction.