Clinical Research Of Traditional Chinese Medicine Treatment Of Endometriosis-related Infertility

Endometriosis (EM) is a disease that a wrong growth of endometrial gland and stroma develop in anywhere of body but inside the uterine cavity, characterized by sterility, dysmenorrhea, persistent lower abdominal pain, irregular menstruation, coitus pain and periods scar pain etc. Currently, EM is increasing in incidence domestically and overseas. As a common disease in gynecology, it a main reason for the sterility of child-bearing period female. Although there is no similar name to ndometriosis?in Traditional Chinese Medicine (TCM), it is classified into dysmenorrhea, sterility, abdominal mass and irregular menstruation in TCM according to some of the clinical manifestation with blood stasis being the root reason, it is usually caused by Qi stagnation, cold-freezing, heat-burning and even injury from operation. Theoretically, Qi stagnation unsmoothens blood flow that will in the long course of time bring about blood stasis. Cold, with a nature of restraining and freezing, can also freeze up blood and result in stasis. Heat contributes to blood stasis by boiling up blood and body fluid or burning down minute collaterals to spill blood. On the other hand, an improper gynecological surgery imposes a direct injury on Chong and Ren channels and uterus, causing deviated blood to become blood stasis, as there is no appropriate way out and sequent source for regeneration. Furthermore, deficiency of Qi, because of the disability to move blood and confine circulation, can slow down the blood circulation and lead to blood leakage as stasis. And accordingly the retained blood stasis in lower abdomen, blocking up Chong and Ren Channels, stuffing uterus and uterine collaterals and affecting Qi and blood movement, turns out to be the cause of dysmenorrhea, pelvic pain and coitus pain. Blockage of stasis, moreover, cuts off the refreshment and attribution of vital blood only to develop 3 menorrhagia and over-prolonged menstruation. And a durable obstruction can also give rise to abdominal masses and sterility for its prevention of feitilization. Being a chronic course associated with Kidney deficiency, which is in charge of reproduction, the relevant sterility of EM is therefore considered Kidney deficiency with blood stasis related in Chinese pathogenesis. Thus, kidney toniflcation and blood elimination ought to be the major therapeutic principle. Modern medical science is still puzzled by the pathogenic mechanism of EM. Many hypothesis were put forward at present including theory of adverse menstruation, endomctrium implantation, coelomic epithelial metaplasia, lymph or vein spreading as well as immunity and genetic 6ctors and so on, among which the 揳dverse menstruation, endometrium implantation?theory is the most acceptable. Factors, including remarkable increase of prostaglandin concentration in pcritoneal fluid together with the quantity and active agent of macrophage; presence of auto antibody like EmAb and dyshormonism such as Luteal Phase Defect, Lutuuzed Unruptured Follicle Syndrome, Hyperprolactinemia, Abnormal Secretion of Follicle Stimulating I-torrnone, were found to be closely connected to the cause of Em-relevant sterility. Recent researches on the Kidney-tonif~抜ng and stasis eliminating treatment prove a remedy fbr those abnormalities. They are providing a strong support for the Em-relevant sterility treatment with Kidney-toniflcation and blood stasis-elimination method. From this...