Berberine Protective Effect On Atherosclerosis Of Renal Injury And Ikk / Of Nf¦Êb Signaling Pathway

Objective To investigate the protect effect of Berberine on atherosclerotic injury.Methods Fifty-six rats were randomly divided into a control group(C),a high-fat diet group(HD),a renal artery stenosis group(RAS),a high-fat diet with renal artery stenosis group(HD+RAS),each in fourteen.C and RAS were given proper diet, HD and HD+RAS were given high fat diet. RAS and HD+RAS were clamped by sliver clip with a fixed diameter on left renal artery. 12 weeks later , executed six of every group for testing,the left were given Berberine(150mg/kg) every day except C,C were given saline .4 weeks later,the left rats were executed for the same testing.Results Compared with C, Creatinine was significantly higher in other three groups(p<0.05). Cholesterol was significantly higher in HD and HD+RAS groups(p<0.05).SOD was Significantly higher while MDA was Significantly lower in HD,RAS and HD+RAS group. After given berberine,the testing results had no significant difference in different groups.Conclusions Berberine has good protection effect on atherosclerotic injury. Objective To investigate the protect effect of Berberine on atherosclerotic injury and its mechanism.Methods Fifty-six rats were randomly divided into a control group(CON),a high-fat diet group(HD),a renal artery stenosis group(RAS),a high-fat diet with renal artery stenosis group(HD+RAS),each in fourteen.C and RAS were given proper diet, HD and HD+RAS were given high fat diet. RAS and HD+RAS were clamped by sliver clip with a fixed diameter on left renal artery. 12 weeks later , executed six of every group for testing,include the out appearance of liver , kidney HE stained ,the expression of ikk-beta in kidney, he expression of VEGF in kidney.the left were given Berberine(150mg/kg) every day except CON,CON were given saline .4 weeks later,the left rats were executed for the same testing.Results Before given berberine ,Compared with CON, the liver of HD and HD +RAS show a yellow pellet change;kidney HE stained prompts glomerular atrophy and renal tubular injury ;the expression of IKK-beta and VEGF were much higher. After given berberine,the testing results had no significant difference in different groups.Conclusions Berberine has good protection effect on atherosclerotic kidney injury through IKK/NF-KB pathway.