Effect And Mechanism Of Mori Folium Extract Solution On Experimental Thrombus

Objective:To investigate the effects of the Mori folium extract solution on rabbit' s experimental thrombus and rat' s experimental thrombus, to afford the new type of anticoagulant for clinic.Methods:The effects of Mori folium extract solution on antithrombosis were investigated in the rabbit thrombus models established by damnified the commom carotid artery with H2O2; The effects of Mori folium extract solution on antithrombosis was investigated on the changes of plasmins and cruor in the venous thrombus models established by ligating the celiac vein among ratsResults:The Mori folium extract solution could alleviate the weight of thrombus, increase the tPA activity and inhibit the PAI activity, so that the content of 6-keto-PGF1a was increased ignificantly (P<0.01) and the content of TXB2 was rdeuced markedly (P<0.05) in blood plasma; The mori folium extract solution could significantly alleviate the weight of venous thrombus, elongate the exsisting time of APTT, PT and TT of plasma, inhibit the PAI activity and increase the tPA activity and AT-Ⅲactivity at the same time.Conclusion:Mori folium extract solution holds significant effects on antithrombosis, which may be brought about by inhibiting the activity of platelet and slowing down the process of activating plasminogen into plasmin; The Mori folium extract solution holds obvious effects of antithrombosis, which may be mainly related to its functions of anticoagulation and its influence on plasminogen system...