Studies On Synthesis And Anticancer Activity Of Some Schiff Bases

According to the studies,it was found that Schiff bases have a variety of use in medicine,organic synthesis,analysis chemistry and catalysis,and so on.Some thiosemicarbazones possess definite antitumor activity.A series of derivatives of Schiff bases such as sulphur-containing Schiff bases and thiosemicarbazones were synthesized.Benzyl-dithiocarbazate's optimum parameters were established by orthogonal tests,whose optimal yield was 77%.Many conditions have been discussed about the reaction.The structures of some derivatives have been characterized by means of IR,MS and HNMR.Three crystal structures of derivatives were determined by single crystal X-ray diffraction analysis. Antitumor activity of sulphur-containing Schiff bases and thiosemicarbazones has also been investigated in vitro.The antitumor activity against man Leukemia MOLT-4 for four compounds J27,J35,J700 and J705 has been tested.The results show that all of them have excellent antitumor activity against man Leukemia MOLT-4,which keep 100 percent during the density change from 10^-8mol.L(-1)to 10(-5)mol.L(-1).Besides,the results show that two compounds J600 and J25 have excellent inhibition effects on SMMC7721 and COLO205 cell growth.The IC₅₀(72 h)of J600 on SMMC7721 and COLO205 cells is no more than 1μmol/L,and that of J25 is no more than 10μmol/L.