The Clinical Effects Observation Of Xuefuzhuyu Capsule Combined With Hormone On Idiopathic Pulmonary Fibrosis And The Changes In Plasma Tnf-α And Il-1β

Objective:To investigate the clinical effects of Xuefuzhuyu capsule combined with hormone in patients with IPF, as well as the effects of Plasma tumor necrosis factor (TNF-a), interleukin 1(3(IL-1β), and to provide new ideas and diagnosis methods in treatment for IPF.Methods:44 patients with IPF were randomly divided into Xuefuzhuyu capsule combined hormone therapy group (18 cases) and hormone therapy group (26 cases). They were administered for 24 weeks. Patients in the hormone therapy group were given prednisone in the dose of 0.5-1mg/kg/d. On this basis, the Xuefuzhuyu capsule combined hormone therapy group combined Xuefuzhuyu capsule treatment. Before and after treatment, Imaging physiology and clinical indicators of changes were observed, and plasma TNF-a and IL-1 were detected.Results:CRP score, clinical scores (C) and physiological (P) scores after Xuefuzhuyu capsule combined with hormone therapy and the hormone therapy were significantly lower than before(P<0.05), except for imaging (R) scores. CRP scores in Xuefuzhuyu capsule combined hormone therapy group were lower than hormone therapy group(P<0.05), plasma TNF-a, IL-1βlevels in two groups after therapy were lower than before(P<0.05).Conclusion:The Xuefuzhuyu capsule combined with hormone can effectively improve the prognosis of patients with IPF, is an effective treatment method. Plasma TNF-a and IL-1βlevels can be used as non-invasive indicators to evaluate clinical severity and treatment of IPF.