Prevalence Of Penile Hpv Infection In Anyang Area Of Henan Province

Objective: High risk HPVs is a necessary factor for carcinogenesis of cervical cancer. The association between HPV and other cancers is undergoing. While much is known about the natural history of cervical HPV infection and its consequences, relatively little is known about the natural history of genital HPV infection and diseases in men. Based on our esophageal cancer cohort study, a prevalence survey of penile HPV infection was conducted.Methods: A questionnaire was used to collect risk related information. The male penile exfoliated cells were collected. The presence of HPV DNA was detected by polymerase chain reaction. Sequencing was employed to determine HPV types. The data was analyzed by SPSS software.Results: HPV DNA was detected in 444 of 2236 subjects (19.86%). Statistical significance was observed among age-stratified groups (P=0.034), and the 25-35 age-stratified group has the highest infection rate. Thirty six HPV types were found in these samples and the most prevalent types were HPV 16, 3, 57, 18, and 87. Non-conditional Logistic regression analysis showed that the factor of multiple lifetime sex parters (OR for multiple lifetime sex parters=2,2.45[95%CI,1.67-3.60], OR for multiple lifetime sex parters≥3,1.98[95%CI,1.42-2.76])and the factor of age of first sexual intercourse>19 years old were associated with HPV infection.Conclusion: HPV infection is common among the male villagers in Anyang. The main risk factor for HPV infection in the general population is multiple lifetime sex partners, and the main protective factor is age of first sexual intercourse>19 years old.