Effect Of Once High-dose Coenzyme A On Postprandial Hypertriglyceridemia After A High-fat Meal

Aims:Postprandial hypertriglyceridemia is an independent risk factor for coronary heart disease and atherosclerosis. This study was designed to explore the effect of once 1000 u Coenzyme A injection or capsule on postprandial triglyceride level after a high-fat meal in Chinese patients with fasting hypertriglyceridemia.Methods:Ten healthy controls and 20 patients with fasting hypertriglyceridemia took a baseline high-fat meal (800 calories; 50 g fat) after diet direction. And blood samples were collected at 0,2,4 and 6h after the baseline meal. On the second day, all patients accepted a high-fat meal again and randomly took 1000 u Coenzyme A orally at 30 min before the meal or by intravenous drip immediately after the meal within 1 h. Blood samples were also collected at 0,2,4 and 6 h after the second meal. Blood lipids levels were assayed and percentages of increment in postprandial triglyceride level at 2,4 and 6h after the meal were calculated.Results:Postprandial serum total cholesterol, high density lipoprotein cholesterol and low density lipoprotein cholesterol levels did not change significantly when compared with their fasting levels, respectively. The postprandial serum triglyceride levels increased significantly at 2,4,6h in patients while only at 2h in healthy controls (P <0.05). Taking all patients accepted Coenzyme A capsule and injection as a total (n=20), a significant decrease was found in percentage of increment in postprandial triglyceride level at 6h after Coenzyme A treatment (62.4±13.1:42.1±9.2%, P<0.05). Subgroup analysis showed that both postprandial triglyceride level at 6h (4.63±2.40:3.80±2.08 mmol/L, P<0.05)and percentage of increment in postprandial triglyceride level at 6h (62.8±17.7:39.0±14.9%, P<0.05) significantly decreased after Coenzyme A injection treatment. However, decreases of postprandial triglyceride level and percentage of increment in postprandial triglyceride level did not reach statistical significance in patients taking Coenzyme A capsule.Conclusions:Once 1000u Coenzyme A injection immediately after meal was shown to be effective to control postprandially increased serum triglyceride level at 6h after a high-fat meal in patients with fasting hypertriglyceridemia. Once 1000u Coenzyme A capsule did not significantly decrease postprandial serum triglyceride levels at 2-6h.