Co-amplification Of Pepsinogen Staining Endoscopy In The Diagnosis Of Early Gastric Cancer

Objective To evaluate the use of latex-enhanced immunotur- bidimetry of serum tests: serum PGⅠ,PGⅡ, PGⅠ/PGⅡratio screen of gastric cancer,and compared pepsinogen advantages and disadvantages of various detection methods, and judge the value of uniting fuji intelligent color enhancement (Fice) in the diagnosis of early gastric cancer.Methods All patients were censused by pepsinogen, as if we discovery people whose pepsinogen were abnormal , they were requested normal endoscopy examine, normal endoscopic suspicious lesions (such as ulcers, stomach cancer, polyps, etc.) then use fuji intelligent color enhancement and endoscopic biopsy targeting, and finally clear lesions.These patients were divided into 7 groups based on endoscopic and histopathological findings: 79 in gastric ulcers group, 138 in chronic gastritis group (chronic atrophic gastritis and chronic gastritis with mild to moderate neoplasia), 22 in early gastric cancer group, 90 in advanced gastric cancer group, 59 in beforing and aftering gastric surgery group, 16 in gastric cancer recurrence group, 75 in other diseases of digestive tract.and 85 served as control group. Identify benign lesions of the PGⅠand PGⅡ, PG Ⅰ/ PGⅡratio of the reference range, and compared with the control group.Compare chronic gastritis and gastric cancer, early gastric cancer and gastric cancer, gastric cancer after preoperative PGⅠand PGⅡ, PGⅠ/ PGⅡchanges.Results Patients with benign gastric ulcer group PGⅠand PGⅡhigher than the control group, PGⅠ/ PGⅡratio decreased (P <0.05).PGⅠand PGⅠ/ PGⅡratio values decreased in Chronic gastritis than the control group,but PGⅡincreased, Gastric cancer patients with PGⅠand PGⅠ/ PGⅡratio of Chronic gastritis were significantly lower (P <0.05), which early gastric cancer and advanced gastric cancer group compared with PGⅠand PGⅠ/ PGⅡratio were not significantly different (P> 0.05).Patients after gastritis surgery PGⅠand PGⅡvalues were lower, PGⅠ/ PGⅡratio increased (P <0.05). Recurrence of gastric cancer serum PGⅠand PGⅠ/ PGⅡratio also increased (P <0.05).Combined with FICE technique we can increase early diagnosis of early gastric cancer with 80%.Conclusions The use of latex-enhanced immunoturbidimetry of serum tests: serum PGⅠ, PGⅡ, PGⅠ/PGⅡratio to screen of Gastric Cancer have impotant application value. As a means of large-scale population survey of gastric cancer, non-invasive, easy to promotion. Pepsinogen combine with fuji intelligent color enhancement can improve the rate of early gastric cancer diagnosis.