The Association Between The Expression Of P53 And Peritoneal Metastasis In Colon Carcinoma

Objective:1. To investigate the expression of p53 protein in colon carcinoma.2.To approch the association between the expression of p53 protein and peritoneal metastasis in colon carcinoma, also with clinical pathological features.Methods:1. The expression of p53 protein was detected by immunohistochemistry S-P method in 60 cases of colon carcinoma and 30 cases of colon carcinoma with peritoneal metastasis.2. SPSS statistical software program (version 13.0, SPSS, Inc.) was used for statistical analysis.Result:1. Detected by immunohistochemistry, the positive expression rate of p53 protein was 51.7%(31/60) in 60 colon carcinoma samples, and 83.3%(25/30) in 30 colon carcinoma with peritoneal metastasis.There was significant difference between two groups(P<0.05). 2. By statistical analysis, p53 protein expression was found to be associated with risk factors such as differentiated degree of colon carcinoma, Dukes stage and lymph node metastasis:the expression of p53 in colon carcinoma of poorly differentiated adenocarcinoma was significantly higher than in colon carcinoma of well and moderate-differentiated adenocarcinoma, the expression of p53 in the stage of DukesA,B was significantly higher than in DukesC,D, with lymph node metastasis was significantly higher than without lymph node metastasis.3. In the case of colon carcinoma with peritoneal metastasis, p53 protein expression was't found to be associated with risk factors such as differentiated degree of colon carcinoma, and ageConclusion:1.The expression of p53 protein in colon carcinoma higher than in 30 colon carcinoma with peritoneal metastasis.2. p53 may play a role in the the occurrence and development of colon carcinoma.