Features Of Glucose And Lipid Metabolism In Women With Polycystic Ovary Syndrome

Objective: To investigate the features of glucose,lipid metabolism and the prevalence of metabolic syndrome in women with polycystic ovary syndrome (PCOS), and to analyze correlative factors of the glucose and lipid metabolism.Methods: 137 patients with PCOS and 116 age-matched normal women were enrolled in this study. (1) Physical examination included height, weight, waist circumference, hip circumference and blood pressure and body mass index(BMI)was calculated. (2) Laboratory parameters included fasting plasma glucose (FPG), 2 hours plasma glucose after the tolerance test with 75g oral glucose(2hPG), fasting insulin (FINS),total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-c) and low density lipoprotein cholesterol (LDL-c). SPSS 13.0 was used for statistical analysis.Results: (1) The prevalence of overweight/obese in subjects with PCOS was 41.6%, with average BMI (27.8±3.39)kg/m~2, and the prevalence of central obesity was 44.6%, both significantly higher than those in control group (P<0.05); (2) The prevalence of type 2 diabetes mellitus (T2DM), impaired glucose tolerance (IGT), impaired fasting glucose (IFG) in subjects with PCOS were 4.4%, 25.5% and 2.2% respectively. According to BMI, subjects with PCOS was subdivided into two subgroups (the overweight/obese and lean). The prevalence of T2DM, IGT, IFG in overweight/obese subjects with PCOS were 7.1%, 35.7% and 3.6% respectively. The prevalence of glucose homeostasis disorders in PCOS group increased significantly in comparison with control group (P<0.05).(3) The prevalence of high TC, TG, LDL-c and low level of HDL-c in subjects with PCOS were 13.5%, 23.3%, 4.5% and 46.6% respectively. 58.6% subjects with PCOS had at least one feature of dyslipidemia. The prevalence of high TC, TG, LDL-c and low level of HDL-c in overweight/obese subjects with PCOS were 22.8%, 35.1%, 10.5% and 68.4% respectively. (P<0.05). (4) The prevalence of metabolic syndrome (MS) was 28.3% in subjects with PCOS, and 57.4% in overweight/obese subjects with PCOS. PCOS patients were characterized by significantly higher prevalence of MS, in comparison with the control group (P<0.05). (5) In women with PCOS, stepwise multiple linear regression analysis showed FPG was correlated with BMI, WC and TG respectively; 2hPG was correlated with TG; TG was correlated with BMI, WC, and 2hPG; both TC and LDL-c were correlated with DBP; HDL-c was inversely correlated with BMI, 2hPG level and WC.Conclusion: The patients with PCOS are accompanied by a higher prevalence of central obesity, impaired glycometabolism, dyslipidemia and MS, and their development risks increase significantly along with BMI increasing.