Analysis Of Multi-risk Factors In Patients With Cerebral Stroke

BackgroundCerebral stroke is one of the most serious disease affecting human health and the third popular reason for death with high prevalence, disablity rate and recurrence, it is increasing each year with aging of the population in China. According to traditional studies, hyperlipidemia, high fibrinogen and platelet were independent risk factors for cerebral stroke.But there were still one third patients who had no classical risk factors,especially for young patients.Studies from other countries showed that the level of serum homocysteine and inflammation factors, especially C-reactive protein were close associated with artery thrombosis. But there are few report about it in China.Deficiency of protein C and protein S are considered as important risk factors for venous thrombosis,but the relationship between protein C and protein S and artery thrombosis is not clear now.To improve clinic physician's cognition of cerebral stroke and prevent stroke more effectively, it is important for us to discuss these risk factors.ObjectTo analyse risk factors including the activity of protein C,protein S, the level of homocysteine and C-reactive protein through case-control study of stroke group and control group and provide more effective clinic data for prevention and threpy of celebral stroke.MetholdA prospective case-control study was carried out,in which 50 patients with acute ischemic stroke,as well as 60 control patients were studied.Blood samples in acute phase of stroke were obtained within 24h after frist onset. Protein C and protein S were measured by chromogenic substrate assay, homocysteine, C-reactive protein, TC,TG, fibrinogen and platelet were measured.T test were assessed in stroke team and health team.ResultsCompared with control patients,in acute stroke,levels of CRP were measured respectively 22.83±14.75mg/L and 5.66±3.89mg/L,there is statistically significant. levels of homocysteine were measured respectively 39.30±30.93umol/L and 26.55±18.13 umol/L,there is statistically significant,too.Levels of PC and PS were (109.36±21.58)% and (82.95±28.19)% respective, slightly lower than that of control group,there was no statistically significant.Among people under 60 years case-control study showed that P value> 0.05,but the t value approached 1.660.It should further study if there was statistically significant in younger stroke patients without traditional risk factors.Compared with control patients,in acute stroke,levels of TC,TG, fibrinogen and platelet had no statistically significant.ConclusionsCRP and Hcy might be important risk factors for stroke. Deficiency of protein C and protein S might conduce to the stroke,especially for young patients.