The Study On The Intervention Of Metabolic Syndrome With Qingxuan Capsule And The Effection On The Fat Factor

Study objective:Many clinical studies confirmed that kidney resistance network for the basic pathogenesis of MS, kidney meridians is the key to treating the disease. In this rule under the guidance of law, development clears dizzy capsule. Preliminary study confirmed that Qingxuan capsule combined with behavioral intervention can regulate blood lipids, lower blood pressure, control blood sugar. In this study, observation lipids, blood pressure, blood sugar, insulin resistance index and other indicators at the same time, be detected on fat factor to explore the blood lipids, blood pressure, blood sugar and fat and other indicators to improve the relationship between changes in factors with a view to clarify Qingxuan Capsules treatment of MS the molecular mechanism of Chinese medicine MS provides a new drug prevention and treatment, new methods, new program.Study Methods:will meet the test criteria of MS were randomly divided into trial group 120 cases,120 cases of the control group, experimental group behavioral intervention (reasonable diet, adequate exercise, quit smoking, reduce stress and depression) based on the taking Qingxuan capsule in the control group in the behavioral intervention on the basis of oral metformin treatment for 6 months. Before treatment, after treatment were observed TCM symptoms, tongue, pulse, blood pressure, body mass index, waist circumference, blood lipids, blood pressure, blood glucose, glucose tolerance, plasma insulin, insulin resistance index, the overall post-glucose load insulin sensitivity index; combined with fat factor the latest progress of the study will affect the IR's fat factors such as:retinol-binding protein-4, visceral fat hormone, adiponectin, resistin, tumor necrosis factor-a into the observation area. In the course of treatment for safety observation (general physical examination items, blood, urine, stool routine, heart, liver and kidney function tests), detailed record of adverse reactions occurred and duration, frequency, clinical management measures and their use of drugs and test the relationship between evaluation.Results:Qingxuan symptomatic efficacy of traditional Chinese medicine capsule test group the total effective rate 85.78%; metformin in the control group, the total effective rate was 62.34%, compared with the two groups were significantly different (P<0.05); the same time, the test group a number of very significant symptom score, or significantly reduced (P<0.01 or P<0.05). Test group to improve fasting and postprandial blood glucose levels, control blood pressure, regulate blood fat and reduce the role of adipocytokines (including retinol-binding protein-4, visceral fat hormone, adiponectin, resistin and tumor necrosis factor, plasminogen activator inhibitor) were significantly better than the control group.Findings:1.MS and fat factors (including retinol-binding protein-4, visceral fat hormone, adiponectin, resistin and tumor necrosis factor, plasminogen activator inhibitor) levels are closely linked.2. Qingxuan capsule can effectively regulate insulin levels and insulin resistance index, an improvement of body mass index, blood pressure and blood lipid levels.3. Qingxuan capsule may be better regulation of the level of adipocytokines.