Cyclophilin A Associated With Sle

Objective Systemic Lupus Erythematosus(SLE)is a systemic autoimmune disease which affects multiple organs, and its etiopathogenisis has not been fully understood. In recent years it has been reported that activated T cell,which highly express CD147 molecule and abnormally secrete interferon gamma , might significantly contribute to the development of SLE. Cyclophilin A(CyPA)is an extracellular ligand of CD147 on T cell membrance,however,its association with SLE remains unclear. Here, our aim is to investigate the pathogenesis of CyPA in SLE.Methods Firstly,CyPA levels in sera from 37 active SLE patients,20 inactive SLE patients and 30 normal controls were detected. Secondly , the rhCyPA (recombinded human CyPA)-mediated migration and activation of Jurkat T cell lines under different conditions were evaluated.Results The serum CyPA levels were significantly higher in the active SLE patients than those in the inactive SLE patients or in normal controls. rhCyPA-CD147 interaction may facilitate the migration and activation of Jurkat T cell lines which express elevated levels of CD147 and interferon gamma.Conclusions CyPA may contribute to the migration and activation of Jurkat T cell lines. Abnormal increased CyPA level in peripheral blood of SLE patient might be closely assossiated with the accelerating chemotaxis and abnormal activation of T cell involved in aggravating SLE.