Triazoles Synthesis And Biological Activity Studies,

Nitrogen heterocyclic ring compounds have important applications and good biological activities.Among of them,researchers give much attention to triazoles for their good biological activities.In order to search for new triazole derivatives with higher biological activities,a series of new triazole derivatives were synthesized.Their structures were confirmed by IR,~1H NMR and elemental analysis.The preliminary biological activities were tested.The relationship between the structures and the fungicidal activities of the compounds has been discussed.Part one:Synthesis and biological activities of 3-substituted phenoxymethyl-4 -amino-1,2,4-triazol-5-thione Schiff basesThe intermediats 3-substituted phenoxymethyl-4-amino-1,2,4-triazol-5-thiones were synthesized by substituted phenoxyacetic acid and 1,3-diaminothiourea.A series of triazolthione Schiff bases were synthesized by the intermediates 3-substituted phenoxymethyl-4-amino-1,2,4-triazol-5-thiones and substitutied aromatic aldehydes. Their structures have been confirmed by ~1H NMR,IR and elemental analysis.The preliminary biological activities to three vegetable pathogens have been tested.The results showed that most of them exhibited good fungicidal activities.The relationship between the structures and the biological activities has been discussed.Part two:Synthesis and biological activities of 3,6-disubstituted-1,2,4-triazolo[3,4 -b][1,3,4]thiadiazolesThe intermediates 3-substituted phenoxymethyl-4-amino-1,2,4-triazol-5-thiones were synthesized by substituted phenoxyacetic acid and 1,3-diaminothiourea.In phosphorus oxychloride,3,6-disubstituted phenoxymethyl-1,2,4-triazolo[3,4-b][1, 3,4]thiadiazoles were synthesized by 3-substituted phenoxymethyl-4-amino-1,2,4 -triazol-5-thiones and substituted phenoxyacetic acids.3-substitutied phenoxymethyl-6 -substituted phenyl-1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles were synthesized by substituted benzoic acids and 3-substituted phenoxymethyl-4-amino-1,2,4 -triazol-5-thiones in phosphorus oxychloride.Their structures have been confirmed by ~1H NMR,IR and elemental analysis.The preliminary biological activities to three vegetable pathogens have been tested.The results showed that most of them exhibited good fungicidal activities.The relationship between the structures and the biological activities has been discussed.