Fipronil Derivatives

Fipronil is the typical representative of benzoyl pyrazole class compounds. Benzoylphenylureas (BPUs) analogues belong to a class of insect growthregulators (IGRs), interferes the chitin synthesis in target pests, causing death or abortive development and is considered to be the third generation of insecticides and used as novel materials for insect control. BPUs type insecticides posses high selectivity, low acute toxicity for mammals, and high biological activity resulting in low application rates, therefore many researchers is attaching importance to this field.In order to explore novel derivatives of aryl pyrazole carbonyl ureas and Benzoylphenylureas (Acylthiourea) of pyrazole which have higher biological activity, we designed and synthesized two series of new compounds according to the principle of combination of bioactive substructure and bioisoteric relationship. The structures of the target compounds have been confirmed by 'H NMR, IR, and elemental analysis.This article synthesized A series, B series and C series and there are 19 compounds, and their structures are as follows.