Analgesic Paste Paste Preparation Process And Quality Standards

ObjectivesThe part of polyacrylic acid (NP700) of the nature and characteristics arestudied as a paste on the new water-soluble polymer materials . To Optimizeextraction and preparation technology for the paste.To study the vitropermeation behavior,and draft quality standards.Methods(1)To study Chuanxiong and Baizhi of Extraction of Process: isoimperatorin andpeulustrin of the extraction of indicators as the evaluation to study ofdifferent extraction of methods on the extraction;The Central composite designis used to optimize Chuanxiong and Baizhi's the best process by usingethanol's concentration, soaking's time, times of solvent as a factors(2)To study Zanthoxylum and Asarum of Extraction technique : The evaluationof extraction of volatile oil and water-soluble components of the index ratewere used as index to investigate water's consumption,soak drug or no soak drug forconforming the matter which is water-soluble and volatile oil whether it isaffected. to optimize Zanthoxylum and Asarum of Extraction technique.(3)To study Paste's Process of technology:①the total evaluation of senseorgan index was used as index obserbation and single factor observation wasused to screen out the change ranges of main matrix.②The orthogonal designwas applied to optimize the best technology of preparation.(4)To study of Paste's percutaneous of absorption:①To use peulustrin in theamount of the indicators studied different acceptation of liquid to affectpermeability②inspected the different infiltration of the amount ofpenetration'senhancement effection③to study of the in vitro release oftransdermal drug delivery by 24h cumulative release of indicators.(5)To study paste's quality standards: 2005 edition Pharmacopoeia and relatedliterature is standard to establish this paste's TLC and Paste method for thedetermination.Results:(1) Chuanxiong and Baizhi were extracted by using 86% ethanol of 30 times tosoak 30 h.(2)The Asarum and the Zanthoxylum were distilled together for volatile oilswith 8-fold water for 4hours.(3)The best matrix proportion of zhitong Emplastrum showed as polyacry acid(NP700,neutrualized partly)to glycerin to tartaric acid to linking agent(AlCl₃:Al(OH)₃)was 2.1 to 15 to 0.023 to (0.019 to 0.013).(4)The best paste of preparation was use A ,which was NP700, glycerol, aluminum hydroxide, with uniform magnetic stirring after ultrasound degassing,thenmixed with D which was borneol, Azone,volatile oil,and mixed with C which isChuanxiong,Baizhi extracted,and mixed with B which is tartaric acid andaluminum chloride,then stirred to the appropriate viscosity after resurfacingin the non-woven fabrics, dry 70 degrees after 2 hours Leng,and can be theAnti-Burn Paper.(5)The equation for in-vitro permeation was Q= 1.0907t+4.8052(r=0.991).(6) Quality evaluation was performed in line with paste as designated in ChinesePharmacopoeia;besides,qualitative and quantitative method was establishedbased on which a quality standard proposal was drafted(≥2mg peulustrin/perpaste).ConclusionThe process technology is feasible and stable . NP700 for Paste as a pasteprepared adhesive. Therefor ,the study is successful in achieving itsobjectives.