The Faerie Shuangdan Dropping Pills Preparation Process

Chest numbness is caused by kinds of disease that blood vessel shrink,the qi and blood in the pulse congeal lead to the deficiency of vital energy in heart, mainly display a disease that pain on chest.The ill machine of disease is marked emptily,the pathology is "the pulse is obstructed,the blood silt ",Chest numbness endanger human's health seriously.So launch the comprehensive research to this kind of disease is good for improve the human physical and mental health and life quality,which have extremely important meanings.This subject is mainly for the patient who suffer the disease of the blood silt and kidney weak.Study,developed the XianLing Shuangdan dripped pills.XianLing Shuangdan dripped pills is root in clinical experience prescription, which is made up of Bark of Tree Peony,Root of Przewalsk Sage,Herb of Shorthorned Epimedium that have the function of invigorate the kidney,strong muscles and bones,dispel the efficiency of the rheumatism.The form of a drug is drip pills,not only give convenience to patients,but also the advantage of high living beings utilizing degree,function fast,produce convenient,with low costs by gather glycol ethylene.Firstly,Research on Bark of Tree Peony abstraction and purification technology.Adopt Vapor distillation choosing the content of water and distillation amount dual factors dynamically investigate for the best method to abstract Paeonol from Bark of Tree Peony.The dregs use the method of orthogonal experiment design and single factor experiment design,choosing Paeoniflorin content as the indexes,We have analyzed the technology of Bark of Tree Peony water decoction and purification with absorbent resin.1 Add 12 quantity water to Bark of Tree Peony and carry on vapor distillation, collect quantity of 8 times liquid out of the steamer heated up,keep 24h in refrigeratory,get crystalloid.It is the best way to abstract the Paeonol from Bark of Tree Peony.2 Abstract the Paeoniflorin from Bark of Tree Peony:Abstract the Paeonol from Bark of Tree Peony:Determined the optimum extraction process of Herba Bark of Tree Peony was extracted with water decoction for 1 times,each time 10 fold water for 1.5hour,amalgamate mother liquor of filtrating and vapor distillation,concentrate to certain volume.3 Liquid drawing get purification before carrying on absorbent resin.Concentrate the liquid to the 0.5g crude drug / ml before deal with 60%of the ethanol alcohol percolationg.4 The research of absorbent resin technology:Select Model M absorbent resin to rich and collect the effective composition of Bark of Tree Peony.The best technology term is that the ratio of the amount of sample and volume of resins is 0.5,the extraction substance with 0.5g medicinal material/mL density passed the resin column that d/l is 1:6 with the 1.0mL/min absorbed speed,washed out with 30%ethanol for 9 times of resin volume with 2mL/min eluted speed.Secondly,the research on thermodynamics and dynamics of absorbent resin absorbing Paeoniflorin,have investigated the M absorbent resin balancing behavior and thermodynamics nature to herbaceous peony glucoside of big hole and resin,get the following conclusion:M absorbent resin fit the Freundlich formula very well.This course is shown as the endothermic hydrogen key adsorption,go on spontaneously,absorb enthalpy become relatively heavy,it is not easy to take off,high temperature help to absorb.Absorbent resin absorbing,the amount of medicine reach to the saturation, the density of medicine has no effect on exchanging the course,when the amount of medicine reaching the amount of the saturation,the medicine is the lower in density,it is the lower to exchange the speed.So in the course of experiment,we should adopt the medicine amount that has just reached the saturation in order to not only fully utilize medicines,but also shorten the course of exchanging.Thirdly,Research on Root of Przewalsk Sage abstraction and purification technology.The hurb Root of Przewalsk Sage use the method of orthogonal experiment design and double factor experiment design,choosing tanshinoneⅡA and salvianic acid B as the indexes,We have analyzed the technology of Root of Przewalsk Sage water reflux and purification with absorbent resin.1 Abstract tanshinoneⅡA and salvianic acid B from Root of Przewalsk Sage. 85%ethanol,1.5 hours for reflux,12-fold solvent and 2 times for extraction. amalgamate and filtrate the liquid,condense into the crude drug of 0.2g / ml,filter, and fetch the insoluble matter,join 40%of the ethanol to disperse and dissolve, make solution density 0.5g crude drug / ml,add water to liquid make solution density 0.Sg crude drug / ml. 2 The research of absorbent resin technology:Select Model AB-8 absorbent resin to rich and collect the effective composition of Root of Przewalsk Sage.The best technology term is that the ratio of the amount of sample and volume of resins is 0.5,the extraction substance with 0.5g medicinal material/mL density passed the resin column that d/l is 1:6 with the 1.0mL/min absorbed speed.Firstly,Joining the liquid of fat-soluble composition,last kind of quantity was the 1.5g crude drug/ml resin;Absorb the speed as 1.0ml/min;And then join distilled water of 5BV,The speed of elution is 1.0ml/min;And then join water soluble composition(The crude drug of 0.5g /ml),Last kind of quantity was the crude drug of 1.5g / ml resin;The speed of elution is 1.0ml/min;Later joined distilled water is 2BV,The speed of elution is 1.0ml/min;Firstly,use 20%of the ethanol eluting the salvianic acid B;Add 70%of the ethanol remove the impurity;Finally,use 95%of the ethanol elute tanshinoneⅡA,The speed of elution is 1.0ml/min. Fourthly,Research on the XianLing Shuangdan dorpping pills preparation technology.Have separately investigated that drips and makes temperature,medicine, proportion of host,melting temperature,the choice of the host,choice of the coolant,etc.The condition is;Melting temperature is 75 degrees Centigrade;The host is PEG4000:6000=1:1;Medicine:Host=1:3;Drip and make 75 degrees Centigrade of temperature,condensation pharmaceutical is methyl silicon oil-100; Condensation temperature:Ice the water bath.This experiment bases on the pharmacology theory of Chinese medicine, exert the traditional Chinese medicine characteristic,it is hopefully to become good effect,convenient,easy accepted by patient in curing blood silt and kidney weak.