Gall Capsule Production Process And Pharmacodynamics Of Experimental Research

DanShu capsules is the ninth kind of newly-developed new drug ,which was a from adaptation development through concerned research on the formula in laboratory, remaining the former recipe of DanShu Granules.The original formula is a experienced prescription for cholecystitis from the affiliate hospital of Traditional Chinese Medical School of Chang Chun.The formula have been internal hospital application for several years. Basic on continually experiment and selection of the component, and combine clinical research of syndrome Differentiation with disease analysis,this experienced prescription have been developed to a Chinese Medicine Compound for treating Hypochondrium pain result from liver-gallbladder dampness-heat syndrome.The reasons of the form adaptation from grunale to capsules are as following:1.To expand the scope of clinical use by using capsules. Half of the component were sucrose in the DanShu grunales.The substance of high suger unable the patient with diabetes to take this medicine.New adaptation of the form could expanding the field of application.2.For rationalization of the preparation process of the form.The former preparation process was decoction, which only abstract the soluble component of the herb ,but lost volatile oil components. The limitation in abstraction of old process adversely influence on the efficacy. In the novel preparation process, the addition of cortex moutan powder substitute to excipient ensure the stability of capsules and reduce the taken does. The adaptation maximize retaining effective components.3.To reduce the medicine taken dose. According to the physico-chemical properties of different effective components,new preparation process adopt decoction and alcohol sedimentation technique to increase the effective components and decrease the taken dose.The result of the research was from the repeatable experiment, analysis and compareion on consideration of factors of medicine properties .clinical application and production The research systematically evaluated the possibility of preparation process subject to effective compotents index, and secondly consult to pharmacodynamic index in order to minimize the taken does with best efficacy.With the guidance of Traditional Chinese Medical theory and chemical components analysis.we constitute a rational science preparation process to solve the problem in the form priority of Traditional Chinese herb compound.The utilization of novel modem technique in the research provide the preparation process with evidence.finally obtain a optimal preparation process by orthogonal design experimental and pharmacodynamic evaluation.