Ace Inhibitor Synthesis Of New Routes And Its Analogues Computer-aided Design

Angiotensin Converting Enzyme Inhibitors(ACEI), which have been developed for last twenty years, are a series of medicines with special pharmacological action and ex -cellent curative effect for cardiovascular and cerebrovascular diseases such as hypert -ension, heart failure, and coronary heart disease, etc. They are the preferred clinical drug that are recommended by the World Health Organization.This dissertation summarizes the actions' machanism, usages, problems and side -effects' cause of ACEIs, and introduces the application of computers in the ACEIs' de -sign and the methods of their synthesis.Based on the research of predecessor and the analysis from existent materal, four new analogs of dipeptides for the inhibition to ACE are designed under the computer's support, with much possibility to eliminate side-effects. Meanwhile, a common route for ACEIs' synthesis is drafted through the investigation of ACEIs' synthesis. Here, this route, including Micheal addition with alkali as protective and NAC method with ETC as acylating agent, goes around the separation of enantiomer and noxious selective hydrogenation. The representative drug, Enalapril, and four new compound designed in this dissertation are synthesized by this route.