Study On The Chemical Constituents And Biological Activities Of The Triterpenoid Saponins From Elsholtiza Bodinieri

This dissertation is composed of three chapters. Chaper 1 reviewed chemical constituents and biological activities of the triterpenoid saponins isolated from the genus Elsholtiza. The investigation on chemical constituents and bioactivities of Elsholtiza bodinieri collected from Honghe, Yunnan Province, was reported in chapter 2. Chapter 3 was a conclusion and expectation of this dissertation.Elsholtzia bodinieri belongs to the family Labiatae, usually grows in the pine forest or on the hillsides, 1200-3000 meters above sea level. It is mainly distributed in Yunnan Province and western region of Guizhou province and other places of our country. As a traditional folk medicine, E. bodinieri was used for the prophylaxis and treatment of cough, headache, pharyngitis, fever, toothache, indigestion, anuria and hepatitis for a really long time. Its tender tip can also be used as herbal tea with the efficacy of heat-clearing and detoxifying. As an important ethnic medicine and health beverage in Yunnan Province, E. bodinieri has good prospects for development and utilization. In order to search for more new secondary metabolites with potential bioactivities, five new triterpenoid saponins, together with 25 known ones were isolated from the titled plant. The results indicated that the major constituents of the n-BuOH soluble fraction of E. bodinieri were triterpenoid saponins, mainly to oleanane and usane saponins. The novelty of sturctures seems to be concentrated among the types and linkage of sugar residues.This paper also studied on the anti-inflammatory activity, turned out some of the compounds from the n-BuOH soluble fraction of E. bodinieri possessed weak activities.