| Skullcap soup came from the "Treatise on the sun · distinguish abnormal pulse and governance," by skullcap, peony, licorice, jujube four herbs composition, with there Pondicherry heat, Pinggan grabbing yin, and the analgesic efficacy, for the sun together with the Shaoyang disease, fever, mouth pain, lower interest urgency, abdominal pain, anal burning, tongue yellow, pulse a few strings. The party was a classic recipe, modern clinical studies for the treatment of damp-heat dysentery, colitis, diarrhea and other intestinal diseases, a significant effect. The latest study found that HQT basis intestinal cancer patients had a certain role in the restoration of the side effects of chemotherapy, but also could prevent or delay resulting diarrhea after chemotherapy. The issue comprehensively reviewed the clinical application of modern skullcap soup, soup made from the skullcap medicine granules, their preparation process were studied to investigate the stability of research and quality standards. Not only retained the features and advantages by the parties, and while it was taking, saved more convenient to carry.These were divided into three parts:Research HQT granule preparation of the first part:the combination of traditional and modern extraction technology comparison test, a clear advantage of modern extraction technology. Developing a cream rate, extract volume, baicalin, total flavonoids content, paeoniflorin as indicators, single factor test and L9 (34) orthogonal test to inspect, a comprehensive analysis of the extraction, concentration, drying and other steps to determine suitable conditions; forming granules through the process of research, select size, moisture and other dissolved as an index to inspect a variety of materials, optimized materials and determine the appropriate amount to determine its molding process. Overall preparation process is reasonable, stable quality, high feasibility.The second part of the quality standard of HQT granules:To control the quality of HQT granules to ensure the stability of its quality, in this experiment, the active ingredients of single herbs and single flavor ingredients for the control to assess the intrinsic quality of drug use TLC preparation skullcap, peony, licorice identify, establish TLC identification method using high performance liquid chromatography, the main component of the preparation skullcap baicalin content was determined, at the same time a methodological study. The eventual establishment of a viable and effective quality control system.Preliminary stability studies HQT granules Part III:sample observation method by agents conducted a six-month stability study at 0 months, one month, two months, three months, respectively, six months at the same time on all aspects of that character, identification, inspection, baicalin content of preparations for testing. Test results showed that selective determination of indicators did not significantly different, all in compliance with the "Chinese Pharmacopoeia" (2010 edition) one, the granules under the provisions of the content, so the stable granule quality skullcap soup. |
