Synthesis And Properties Of Stimuli-responsive Hyperbranched Macromolecules With Double Hydrophilicity

With the rapid development of polymer science, tree-like molecules have attracted more and more interests of polymer scientists. Tree-like molecules, which consists of a series of branching segments, can mainly be classified into two parts, dendrimers and hyperbranched macromolecules. While synthesis and application of hyperbranched polymers may be more attractive because of their unique construction.On the other hand, unimolecular micelles can be synthesized by virtue of self-assembly approach, inorganic template approach, tree-like molecule approach and so on, but the former two approaches have some disadvantages on usage, storage and stabilization and so on. So unimolecular micelles based on tree-like molecules have obtained more and more attention. Among reported studies, unimolecular micelles formed from hydrophilic core grafted with hydrophobic chains or hydrophobic core tethered with hydrophilic chains have been greatly discussed, but the study on unimolecular micelles that are based on biocompatible as well as hydrophilic core grafted with hydrophilic chains has been less concerned.In the dissertation, we firstly prepared hydrophilic hyperbranched core HPG, then functioned and tethered with hydrophilic chains to get double-hydrophilic hyperbranched polymers using living polymerization. Then, we studied the unimolecular phase transition behavior at a low concentration as well as the association and dissociation behavior at some relatively high concentrations. Finally, we explored the resultant hyperbranched polymers to act as in-situ nanoreactors for the synthesis of nanoparticles and the formation of hybrid unimolecular micelles.Moreover, we conducted ATRP technology to synthesize a series of four-armed block macromolecules with stimuli-responsive abilities.