Acute Hypoxia Gansu Zokor Heart Antioxidant Enzymes And Atp Enzyme Activity Study

Gansu zokor is a unique subterranean rodent which lives on the loess Plateau of our country.This unique underground rats life-long living under the cave,it developed many mechanism to adapt its special circumstances at all levels.In my study, we used Gansu zokor and SD rats for the object, acute hypoxia stimulation, analysis and comparison of the level of SOD activity,CAT activity,GR activity,Na+,K+-ATPase activity,Ca2+-ATPase activity,Ca2+Mg2+-ATPase activity and determinechanges of malondialdehyde (MDA) level.Trying to find the hypoxia adaptive mechanisms of Gansu zokors' myocardial.The results are as follows:1. The level of SOD activity of Gansu zokor was higher than the level of SOD activity of SD rats. There was a very significant difference between female SD rats and female Gansu zokor at 2 hours of hypoxia(P<0.01).And There was significant difference between female SD rats and female Gansu zokor in hypoxia 4h,6hand 8h; There was significant difference between male SD rats and male Gansu zokor in the different terms of acute hypoxia(0.010.05),But the MDA Content of female SD rats had a significant change in the different terms of acute hypoxia (0.010.05). The level of Ca2+-ATPase activity of Gansu zokor showed a significant increasing tendency in two hours and 2-3 hours of activity can be maintained. In that case, Calcium concentration of Gansu zokor remained at a relatively stable level to avoid the damage of myocardial fibers.6. The level of Na+,K+-ATPase activity of Gansu zokor was higher than the level of Na+,K+-ATPase activity of SD rats in the different terms of acute hypoxia. The level of Na+,K+-ATPase activity of SD rats showed fluctuation tendency, Compared with normoxia group, The level of Na+,K+-ATPase activity of SD rats had no significant change in the different terms of acute hypoxia (P>0.05). The level of Na+,K+-ATPase activity of female Gansu zokor showed a significant increasing tendency in four hours,and The level of Na+,K+-ATPase activity of male Gansu zokor showed a very significant increasing tendency in four hours. In that case, Sodium and potassium concentration of Gansu zokor remained at a relatively stable level to avoid the electrical activity of cardiac disorders, cardiac dysfunction.In conclusion,studying on Antioxidant enzymes and some ATPase of Gansu zokor's myocardial in acute hypoxia showed that:Gansu zokor may smooth launch of its own mechanism to hypoxia from molecular,cellular level to the overall coordination,and to adapt hypoxia.