.60 Min Swimming Study On The Effect And Mechanism Of The High Fat Diet Rats Lipid Metabolism Disorders

Objective: By observing 60min swimming exercise on high-fat diet rats which includes activity and higher targets regulate lipid metabolism mechanism of action from plasma LPL,HL,ApoCⅡ,ApoCⅢ, and to analyze the index correlation of each target with ApoCⅡ, ApoCⅢin order to provide a theoretical basis for prevention and control hyperlipidemia.Method: Six-week-old male SD rats with 24, were randomly divided into normal control group, high-fat model group, high-fat 60-min exercise group. Each group has eight. Exercise group undertake Non-weight-bearing swimming exercise for 10 weeks exercise. After 10 weeks, the detection of lipids (TG, TC, HDL-C, LDL-C), LPL, HL, ApoCⅡ, ApoCⅢis to study the appropriate exercise to discuss high-fat metabolize affect and mechanism of action with suitable athletics to high-fat meal rats.Result:1. Before experiment, the rats were no significant differences in body weight. During the experiment, the food of the rats intake was not statistics signification. After 10 weeks, high-fat model group compared with the control group which body weight increased significantly (p<0.05). High-fat 60min exercise group compared with high-fat model rats which body weight decreased significantly (P<0.01). hint: 60min swimming exercise could prevent high-fat meal fats weight gain.2. After 10 weeks, high-fat model group rats TG, TC, LDL-C were significantly higher than normal control group(p<0.05, p<0.01, p<0.05); high-fat 60min exercise group high lipid model group TG, TC were significantly lower (p<0.01, p<0.01); high-fat 60min exercise group density lipoprotein in blood HDL-C group were significantly higher (p<0.05). hint: 60min swimming exercise could put right rat metabolize turbulence of high-fat meal rats.3. After 10 weeks, high-fat model group plasma LPL levels compared with normal control rats which was significantly lower (p<0.05); fat 60min exercise group compared with the model group rats, the level of plasma LPL increased significantly (p<0.05). High-fat exercise group compared with control group plasma LPL levels were not significantly different, indicating 60min swimming high fat diet can increase plasma LPL levels to normal, improving lipid metabolism. 4. After 10 weeks, high-fat model group plasma HL levels compared with normal control rats was significantly higher (p<0.01); high-fat 60min exercise group compared with the model group rats, plasma HL was significantly lower (p<0.05). Fat exercise group compared with control group plasma HL levels were not significantly different, indicating 60min swimming high fat diet can reduce plasma HL levels to normal, so as to improve lipid metabolism.5. After 10 weeks, High-fat model group rats compared with normal control group, ApoCⅡactivity in blood is significantly lower (p<0.01), 60min exercise high-fat rat model of high blood ApoCⅡgroup were significantly l higher (P<0.05). ApoCⅡis LPL activation factor, indicating that lipid metabolism in the regulation of the mechanism, ApoC also play an important role.6. After 10 weeks, high-fat model group rats than in normal control rats, serum ApoCⅢactivity was significantly higher (p<0.05), 60min exercise fat fat rat model of high blood ApoCⅢactivity of rats are significantly lower ( P<0.01). Experimental data show that ApoCⅢof the LPL, HL activity was significantly inhibited, indicating that ApoCⅢmechanism in the regulation of lipid metabolism also play an important role, but the exact mechanism remains to be explored further.7. Experimental data dependence analysis shows, ApoCⅡand LPL there was a significant correlation (p<0.01), with HL was no significant correlation; ApoCⅢand LPL there was a significant negative correlation (p<0.01), with HL significant negative correlation (p<0.05). This shows that the LPL, HL regulate lipid metabolism process, the activity of ApoCⅡon the LPL activity has a significant impact, and the activity of ApoCⅢon the LPL, HL activity has a significant inhibitory effect, especially on LPL activity in the inhibition even strong.Conclusion:1.10 weeks 60min exercise can prevent weight gain of high-fat diet rats.2.10 weeks 60min exercise can prevent high fat diet quality of metabolic disorders in rats.3.10 weeks 60min exercise can increase the activity of ApoCⅡ, thereby regulating the activity of plasma LPL in high fat diet, eventually correct lipid metabolism disorder phenomenon of high fat diet rats. Experiments show, ApoCⅡis essential activator of the LPL. The activity of ApoCⅡand activity of HL had no correlation.4.10 weeks 60min exercise can significantly lower the activity of HL , while HL and HDL-C was negatively correlated, the activity of HL by regulating the level of HDL-C to regulate lipid metabolism.5.10 weeks 60min exercise can reduce the activity of ApoCⅢ, and ApoCⅢis a factor inhibition of LPL, so the activity of ApoCⅢchanges can regulating lipid metabolism has significant influence on LPL. Experimental data hents, ApoCⅢhas not only very significant correlation with LPL, but the changes on the activity of ApoCⅢcan inhibit the activity of HL changed, indicating that level of the activity of ApoCⅢon the proc ess in the regulation of lipid metabolism also play a significant impact.