| Adenine is indispensable for plant. It is an important part of nucleic acid, ATP, coenzyme and second messengers (e.g. cAMP). And its phosphate can accelerate leukocyte's hyperplasia. Therefore, the research on the adenine is very significative. We synthesize binuclear adenine-Cu(Ⅱ) complex, and the single-crystal structure of the complex is not reported in the literature.First of all, as the adenine's simple model, ethylenediamine was used to synthesize [Cu(NH2CH2)2·2H2O] (CH2NHCOO)2·2H2O single-crystal and determined it by X-ray diffraction. Its data were necessary for synthesizing the adenine-M complexes.We synthesized adenine-Cu(Ⅱ) complex and adenine-Ni complex. From the determination of elemental analysis and the UR spectral analysis, we inferred their possible molecular formula and confirmed the coordination of the N from adenine.The bacteriostatic action of adenine, adenine-Cu(Ⅱ) complex and adenine-Ni complex were tested at different concentrations by single paper disc method. The result shows that adenine doesn't have bacteriostatic action. However, its two metal complexes have good inhibitory effect to bacteria. And we discussed their possible antibacterial mechanism and inferred that adenine-Cu(Ⅱ) complex is binuclear copper (Ⅱ)complex.The single-crystal structure of binuclear adenine-Cu(Ⅱ) complex has been received and determined by X-ray diffraction. The analysis of its structure indicates that the every Cu(Ⅱ) ion in the complex is five-coordinated by four nitrogen atoms from different adenine anions and an oxygen atom from water molecule to form two paralleled distorted tetragonal pyramid geometries, which belongs to the SYN-SYN. The characterization of the complex is identical with the determination of crystal structure and bacteriostatic action. |
PDF Full Text Request