Method Analysis Of Cefodizime Sodium For In-jection Of Product Quality

Cefodizime sodium belongs to the third generation semi-synthetic β-latam antibiotics, and was developed by Hoechst GmbH and the French company Rossel. It was firstly lunched in Japan in1990. In1997it entered Chinese market as the brand of "Modivid". The main producer is Lukang pharmaceutical company, Lizhu synthetic pharmaceutical company and Shantou Jinshi pharmaceutical company since2001. Cefodizime sodium is the only one Cephalosporin which has strong anti-biological activity and immunomodulating activity. Since its excellent clinical effect it has been expected one of the most promising product.At present, the quality standard of Cefodizime sodium hasn’t been fully improved and hasn’t been recorded by Chinese Pharmacopeia, so much research work should be carried out.In this thesis, the analytical method research was done for the appearance; identification;acid-base degree; colorance; related substance; content; poly-substance; water contents,sterilization et al.. And the difference between the imported product and the self-prepared product was contrasted. The method of the determination of the poly-substance was established.In conclusion, the much more exclusively, simply and quickly HPLC method was established for the determination of the contents and related substance of Cefodizime sodium. The qaulity standard was set up for the controlling the qaulity of Cefodizime sodium.