Preparation And Application Of Mesoporous Silica/Polymer Composite Nanoparticles

Mesoporous silica nanoparticles (SiO2) have received considerable attention in thebiomedical applications due to their unique advantages (such as high surface area,large pore volume, controllable pore size and pore structure, and tunable size andmorphology), and have become a hot topic of research. In this study, mesoporoussilica nanoparticles with different morphology were prepared using a sol-gel method.Preparation of polymer coated SiO2were then systematically explored. Finally, a kindof double-walled hollow polymer nanorod was designed and its potential applicationswere studied in biomedical and biological fields.This dissertation includes three main parts: In the first part, based on the CTAB as atemplate agent the mesoporous SiO2nanoparticles with uniform particle size andgood morphology have been synthesized quickly by the hydrolysis of TEOS underalkaline conditions. XRD and TEM analysis results showed that SiO2possess anordered mesoporous structure. In the meantime, the processes and conditions ofsynthesis were researched, and a mechanism of preparing mesoporous silica nanorodwas proposed.The second part is mainly on the fabrication of silica/polymer composite nanorods.In this part, we choice two kinds of smart polymer materials as the shell andmesporous silica nanorod as a template, the two kinds of smart polymer materialswere successfully grafted onto the surface of SiO2nanorods by the chemical couplingmethods. While we provides a fast and efficient method of preparation of polymercoated SiO2composite nanorods.The third part is mainly the design and synthesis of double-walled hollow polymernanorod (PMAA@CS), and the investigation of its potential applications inbiomedical and biological fields. Fluorescence microscope images show that the highefficiency of cellular uptake of nanorods in human lung carcinoma cells after A549cells were incubated with the PMAA@CS-FITC for4h. Results of MTT show thatPMAA@CS nanorods have a good biocompatibility and have a higher inhibition ratein tumor cells compared to the free docetaxel. We give the prepared materialscharacterization and analysis in each part, and hope to synthesize nanomaterial that has potential applications in biomedical and biological field.