Biochemistry Kinetics Theory On Transient Response Of Muscle Contraction

The biology research suggests that force production in muscle takes place via the molecular interaction between the myosin heads and their binding sites on actin filaments. This process is driven by the free energy change associated with ATP breakdown to ADP and P; (inorganic phosphate). By the experimental study of transient response in isometric muscle, it was found that the increase in force was well fit by a double exponential equation. However, there is still no theoretical explanation about these experimental results. Based on the simplified four-state model, the chemical kinetics equation describing the collective behavior of myosin was given by this paper, and the expression of transient response on isometric muscle contraction were established by solving the analytical solutions. The theoretical results were basically consistent with the experimental observations.The text is divided into four chapters.In chapter one, the structure of muscle and the sliding mechanism of muscle contraction are introduced. In chapter two, the molecular structure and function of myosin and the mechanochemical actin-activated myosin ATPase cycle are introduced. In chapter three, some experimental results of muscle contraction are introduced. Chapter four is the main part of this paper, in which the theory of transient response of muscle contraction was established, and the relationship between transient response force and the time course was given. In addition, the theoretical results were compared with the experimental results.