MicroRNA181a Regulates Lipid Metabolism Through Targeting IDH1

It has been proved that microRNAs can regulate many physiologic processes and metabolism pathways, though binding to the3’UTR of their target genes. Recent years, a large number of researches have reported the important function of microRNAs. It has been known that microRNA-181has a widely roles in different physiological and pathological development. We all know that miR-181can regulate the differentiation of immune cells, inflammation response, viral resistance and immunoregulation. Besides, miR-181can also regulate the differentiation of cancer cells, promote apoptosis, inhibit cell proliferation.In this paper, we forced on the relationship between miR-181a and lipid metabolism. We proved that miR-181a can target IDH gene to regulate the lipid metabolism, promoting the P-oxidation and inhibiting the synthesis of fatty acids. Overexpressing the miR-181a in mouse can lead to the decrease of the weight, but not induce the cancer or death. As a result, miR-181a can regulate the lipid metabolism, which can be as a method to cure many diseasese, including hyperlipemia and atherosclerosis.