| Become the heart of China's diabetes and cerebrovascular diseases, cancer, another serious hazard after the health of the people the importance of chronic non-communicable diseases and the incidence is rapidly rising trend. Diabetes, acute and chronic complications involving multiple organs, disability, death rate, patients with serious impact on the physical and mental health, and to individuals, families and the community a heavy burden. Diabetes prevention and control work should adhere to the principle of prevention first, to control the upward trend in prevalence of diabetes, reduce complications and improve survival in patients, the objective of improving the quality of life. To achieve this goal, an active research and development and promotion of early diagnosis of diabetes technology is an important work task.At present, the clinical detection of diabetes and patient self-testing is mainly electrochemical and colorimetric assay, often through minimally invasive venous blood or fingertip blood sampling to detect the concentration of blood glucose, which will not only increase the suffering of patients, and detection slow, but not continuous monitoring. Thus, the active principles based on the new non-invasive detection of diabetes research and technology development at home and abroad in recent years has become one of the hot spots.Respiration is an important parameter of life, can often respond to human health, disease status and parameters of life. People of various respiratory gases in a certain range is to maintain dynamic balance, health is a basic human exhaled oxygen, carbon dioxide, water vapor, nitrogen, rare gases and a variety of metabolites, such as. If there are specific gases or gas concentrations in excess of a normal range, often means that the person is about to or have been sick. Modern medicine through the study of disease pathogenesis and clinical testing, patients with a powerful illustration of some of the gas composition of exhaled do in a particular area and physical diseases. This makes it through the analysis of exhaled gas composition to diagnose the disease as a clinical diagnosis traditionally a workable solution. Detection of respiratory modern pathology is mainly found in one or more highly correlated with the disease of the respiratory gas analysis and determine the condition. Generally speaking with simple equipment, easy to operate, without damage to the patient and the accuracy of the characteristics of high technology. Is a good development prospects of medical non-destructive testing technology.An important complication of diabetes will lead to ketoacidosis, significant harm, it is the blood concentration level of acid the body is directly related. Ketoacidosis can cause respiratory gas content increased acetone, acetone is a relatively excessive fatty acid cleavage product of the time. Fat metabolism in normal and balanced state of dynamic transformation, the intake of fat digestion and absorption in the intestinal blood circulation and lymph after hepatic and adipose tissue, but also by the oxidation of convergence for the enzyme acetyl-A. Convergence-A majority of acetylcholine and glucose metabolism in the formation of oxalic acid combined into the three-carboxymethyl cycle, that is completely decomposed into CO2 and H2O; part to fat storage; part by the liver into ketones, blood circulation to the muscles in particular transit it is organizations such as cardiac and kidney and oxidation. Therefore, the normal blood circulation, only trace ketone (0.5 mg%), but not at any time and the accumulation of oxidized for ketonemia.When people with diabetes, because lack of insulin, use a large amount of body fat have been made to speed up the process of ketones and oxidation to enhance the use of the slow-down in the body is a result of excessive fatty acid cracking caused by the relative increase in acetone, causing respiratory gas content in the acetone increased exhaled and thus can be used for the detection of diabetes. There are experimental results show that: breathing acetone and positive relationship between blood sugar and diabetes acetone content of the breathing range: from 50ppm to 400ppm, and, the more serious cases of respiratory illness in the higher content of acetone. Therefore, by detecting breath acetone content to diagnose diabetes is a scientific basis for the clinical detection technology.This article is a developed respiratory acetone-based non-destructive testing device diabetes. The device has a non-invasive test is simple and fast detection advantage. Can be applied to early clinical diagnosis of diabetes, more promising is that if installed in public places, more people will be able to use the device at any time to check for diabetes, which greatly improve the rate of early diagnosis of diabetes, which to improve the quality of life in patients with diabetes, reduce complications and improve survival rates of great significance. In this paper, a comprehensive understanding of gas detection technology based on a high-precision sensors and acetone gas core microprocessor technology and amplification, filtering, A / D conversion, LCD digital display, temperature compensation technology and specialized software supported portable device for rapid detection of diabetes design.Sensor selection Alphasense company's products, with good combination of the pre-circuit, so that breathing in the range of 0-200PPM the acetone gas detection with high sensitivity, fast response, good repeatability, long life, such as technical characteristics.Selection of small, cost-effective the United States Dallas Semiconductor's new digital temperature sensor DS18B20 up as temperature sensors, so that the device in +20℃~ +50℃within the scope of work to achieve an effective precision of the temperature compensation to improve the detection accuracy.National Semiconductor Corporation in the United States ADC121S101 models of the 12 serial A / D D converter consisting of simple structure, low power consumption, conversion of high accuracy and low cost advantages.Chinese font LCM12232ZK with the use of the dot-matrix liquid crystal display modules with multi-display function, and single-chip microcontroller, such as a flexible interface, a wide range of power operation, low power consumption characteristics, is very suitable for portable systems applications.Modular design of software programs, including the main program and data measurement, system calibration, LCD display, temperature compensation, keyboard subroutine.One of the characteristics of system calibration subroutine is the first in accordance with the characteristics of the sensor, the selected calibration standard above the required number of N, each corresponding to a period of a few standard acetone gas concentrations, a total of Q0, Q1, Q2, Q3 ,---, QN . On any one of the standard concentration of QX, through changes in key selected in the LCD display on the concentration of the gas through the gas into the sensor chamber, measuring the average of M times and after the check deposited into the designated single-chip memory cell, the The standard is the average concentration of acetone gas sensor characteristics of the corresponding voltage value. And so on, the completion of the characteristics of the N voltage sensors comprising VX calibration data sets. N values of the greater accuracy of calibration set higher.The design has a higher detection accuracy, detection speed and ease of use and other technical characteristics. Is a better value of the new non-invasive diabetes detection device. |
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