Research On Mathematical Model Establishing And Numerical Simulation Of Microfluidic In Lab-on-a-Chip

In the past 10 years,the technology of Lab-On-a-Chip(μTAS) has become one of the forefront fields. It has notable characters of fast analysis, high amount of information, low operating costs, small consumption of sample, and small pollution.As the development of MEMS andμTAS, the research on the microfluidic and Nano-scale fluid is becoming a key point, which has great significance to the microfluidic control and optimal design of devices in Lab-On-a-Chip. More precise control of the microfluidic in Lab-On-a-Chip can achieve the functions of the entire chip better, so quantitative research on it is important to the design and analysis. And theoretical support is needed to make quantitative analysis onμTAS.Firstly, this paper has concluded about the development of Lab-On-a-Chip and its numerical study of microfluidic. The paper also has model established, which based on the microfluidic with the Navier-Stokes equation, Continuity equation, Boltzmann charge distribution and Poisson equation, and simplifies the model according to the characteristics of microfluidic. Through the computer numerical, the paper gets the distribution of potential, velocity and flow field under different conditions, which can avoid the blind experiment, raise the efficiency of experiment and provide valuable reference for the territory of electrophoresis chip design.This paper discusses the micro-scale effects of the microfluidic and analyzes of the difference between the macro-fluid and microfluidic. It analyzes the potential distribution through the finite element method, compares the result with the original model and simplifies formula about the potential distribution and charge density distribution in the double-layer. This paper solves the potential distribution of a rectangular cross-section microfluidic and circular section micro-channel and makes comparative. And it studies the EOF effect through computational fluid dynamics method and finite difference method. This paper gets the simplified formula of the electroosmotic flow and makes comparative with the pressure-driven microfluidic.This paper makes analysis about electric field which can drive microfluidic through finite difference based on the principle of Lab-On-a-Chip.Finally, the paper makes analysis about the microfluidic with the software ANSYS, in order to decrease the difficulty of solving electroosmotic flow. After the reliability verification of the software analysis, it also studies the affection factors about the microfluidic.