Remote Computing Platform Of Metabolic Networks Simulation Based On Cluster

The metabolic networks research is very significant in life science study. Based on stoichiometry, flux balance analysis method has its advantages in reconstructing and explaining the systemic characters of metabolic networks. As to the complex computing and requirement in real-time service, the high performance computer is needed. To solve the above problems, a cluster and web based remote computing platform is developed, which is multi-user oriented, high performance computing, and can be used in the biological metabolic networks research.Because of the using of Java programming language and multi-layer framework design based on the browser/server three-layer framework, the system has the characters of flexibleness and independence. The well interaction of graphical operation interface makes the platform easy to be used by biologists without caring the complex computing process.This platform uses cluster as serried computing background, adopts the centralized task scheduling and load balancing, so that it can afford the processing of multi-client requests, reduce users'waiting time and enhance the efficient by adding the cluster's scheduling and parallel computing ability. The message passing interface and remote method invocation are also used to implement the communication between the computer nodes.Based on the system development, the energy metabolic network in mammalian myocardia was reconstructed as an example, and the platform's usability and validity were proved through the simulation. The test result to the scheduling and load balance indicated that the system works well and can catch our prospective purpose.