| Purpose:Investigate the distribution of different TCM syndromes in the patients with type 2 diabetes with coronary heart disease, analyze the risk factors among different syndromes,and explore the relationship between syndrome and indicators or other complications.Material and method: Cases of Endocrinology of hospitalized patients with type 2 diabetes with coronary heart disease were collected from Affiliated Hospital of Liaoning University of Traditional Chinese Medicine from June, 2013 to Janurary,2015. Then analyzing the distribution of TCM Syndromes of the disease according to dialectical situation. Divide the patients into different groups according to their syndromes,and count the relevance between syndromes with gender,ages,the course of DM, Body Mass Index, Fasting blood glucose, glycosylated hemoglobin A1, blood pressure, lipids, myocardial enzymes level and complications based on the groups.Results:1. 164 cases,78 males and 86 females, were included, the average age of whom was62.65±11.41 years old. The TCM syndromes and their number of cases are: Qi and yin deficiency with blood stasis(101 cases), yin and yang deficiency with blood stasis(32 cases), deficiency of yin between liver and kidney with blood stasis(27 cases),phlegm and blood stasis(2 cases), deficiency of yang between heart and kidney with blood stasis(1 case) and hyperactivity of yang of liver with blood stasis(1 case). The number of qi and yin deficiency with blood stasis, accounting 63.13% of the total number is the most(P<0.05).2. There are not enough cases in the syndromes of phlegm and blood stasis, deficiency of yang between heart and kidney with blood stasis and hyperactivity of yang of liver with blood stasis according to result 1, so we just compared correlated data of the other three syndromes of 160 cases by dividing them into three groups.3. General information:(1) Gender: 160 cases, 76 males and 84 females, wereincluded, and there was no statistically significant difference in gender(P > 0.05).Intra-/inter-group comparisons in gender were also insignificant(P>0.05).(2) Age:The average age of the 160 cases was 62.66±11.54 years old. The patients whose average age was 71.28±9.16 years of yin and yang deficiency with blood stasis were older then the other groups(P<0.05).(3) The course of DM: The average course of the 160 cases was 130.70±87.36 months. The patients whose average course was92.86±50.78 months of qi and yin deficiency with blood stasis were shorter then the other groups(P<0.05).(4) BMI: The average BMI of the 160 cases was 25.62±3.30kg/m2 and there was no statistically significant difference in it(P>0.05).4. Clinical information:(1) Blood glucose: The average fasting blood glucose of the160 cases was 9.45±2.15 mmol/L and Hb A1 c was 8.50±1.47 %. There was no statistically significant difference in FBG and Hb A1c(P>0.05).(2) Blood pressure:The average systolic blood pressure of the 160 cases was 138.69±13.30 mm Hg and diastolic blood pressure was 80.54±11.30 mm Hg. There was no statistically significant difference in SBP(P>0.05) when it was statistically different in DBP(P<0.05).The DBP of qi and yin deficiency with blood stasis was higher.(3) Blood lipids:The average TC, TG, LDL-C, HDL-C of the 160 cases were: 5.08±1.42 mmol/L,1.89±1.13 mmol/L, 2.99±1.08 mmol/L, 1.20±0.32 mmol/L. There was no statistically significant difference in TG and HDL-C(P>0.05) when it was statistically different in TC and LDL-C(P<0.05).The TC and LDL-C of qi and yin deficiency with blood stasis were higher.(4) Myocardial enzymes: The average LDH, CK, CKMB, HBDH of the 160 cases were: 171.93±35.48 U/L, 97.45±51.74 U/L, 13.74±6.99 U/L,139.01±31.695 U/L, and there was no statistically significant difference in myocardial enzymes(P>0.05).5. Complications: The complication incidence rate from high to low of 164 cases of T2 DM with CHD were: hypertension(71.59%), dyslipidemia(53.05%), diabetic lower limbs atherosclerosis(36.59%), diabetes peripheral neuropathy(33.54%),osteoporosis(20.12%), diabetic nephropathy(17.68%), diabetic retinopathy(14.02%)and cerebral infarction(12.20%). The dyslipidemia incidence rate of qi and yindeficiency with blood stasis was higher(P < 0.05) when diabetic lower limbs atherosclerosis and diabetes peripheral neuropathy were much more in the syndrome of yin and yang deficiency with blood stasis(P<0.05).Conclusion:1. Qi and yin deficiency with blood stasis, yin and yang deficiency with blood stasis and deficiency of yin between liver and kidney with blood stasis are three mainly TCM syndromes of T2 DM with CHD, and the patient of qi and yin deficiency with blood stasis is the most.2. The TCM syndrome of T2 DM with CHD is associated with age, the course of DM,blood lipid: The patient who is older or has longer course of DM is usually yin and yang deficiency with blood stasis; the patient whose TC or LDL-c is higher usually is qi and yin deficiency with blood stasis.3. The TCM syndrome of T2 DM with CHD is not definitely associated with gender,BMI, FBG, Hb A1 c, blood pressure and myocardial enzymes, but BMI, FBG, Hb A1 c and SBP are important risk factors for the disease.4. The patients of T2 DM with CHD are the most easily complicated with hypertension. The patients of qi and yin deficiency with blood stasis are more easily complicated with dyslipidemia. Diabetic lower limbs atherosclerosis and diabetes peripheral neuropathy are usually happened to yin and yang deficiency with blood stasis. |
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