Study On The Relationship Between Physical Fitness And Correlation With FT3, FT4 Normal Chronic Lymphocytic Thyroiditis

BackgroundChronic lymphocytic thyroiditis (CLT) (referred to chronic thyroiditis) is an organ-specific autoimmune diseases that the thyroid is widely infiltrating lymphocytes as the main pathological manifestations,and cytokines and thyroid specific antibody plays a role in the disease progression and triggeras,a subtype belonging to autoimmune thyroiditis (AIT).Hypothyroidism is a natural outcome of this disease,it is caused by the growing importance of clinicians.Early diagnosis of the disease and reduce the misdiagnosis rate is conducive to the sound development of the prognosis.The disease is insidious onset and progressive.Although modern treatments,such as hormone replacement therapy, immunomodulation therapy,surgical treatment,achieved some clinical effect,there are still limitations and side effects that can not be ignored.The theory on constitution in TCM on the development of modern Chinease medicine is growing.Presently,many diseases are proposed the concept of distinguishing constitution-disease diagnosing-syndrome differentiation,so taking advantage of distinguishing body constitution assisting syndrome differentiation and treatment variation,a latest development direction of body constitution therapy.The pour of body constitution and particularly biased constitution has susceptibility to disease progression tendentious,but the constitution itself is adjustable,which makes biased improve physical fitness,disease prevention and treatment possible.In the early CLT often euthyroid but higher thyroid-specific autoantibodies,which not only indicates that thyroid dysfunction,may also lead to recurrent pregnancy abortion,but this time highlighting the limitations of Western medicine,the use of Chinese medicine for immunomodulatory advantages and the theory of constitution about not only disease prevention,but aslo diseases anti-change in the early shorten the course and preventing the progression of the disease by adjusting the type of body constitution become a new vision for the treatment of the disease.Now research body constitution in TCM and CLT is not much,but some of distribution of CLT constitution remaining lack of systematic,blended constitution on the few studies,which can not recognize the whole constitution distribution of the disease circumstances,affect the clinical efficacy of Chinese medicine treatment of chronic thyroiditis.ObjectiveThis study was based on epidemiology,TCM constitution scale investigation by exploring patients’ with CLT sex,disease duration,age,body constitution type and distribution and TPOAb,TGAb,level of thyroid function in patients with thyroiditis objective index correlation,so as to apply TCM constitution theory to guide clinical syndrome differentiationl,pioneering medication,diet ideas. Therefore there is may significant improvement in thyroid autoimmune disorders inflammatory state,by adjusting the constitution to shorten the course of the disease or even basis theoretical for curing diseases.MethodsReferring to CLT diagnostic criteria in"Guidelines for the diagnosis and treatment of thyroid diseases in China"by the endocrine branch of the Chinese Medical Association,102 patients with CLT was screened from 330 patients by meeting the inclusion criteria of this study and not having the standard of ruling out and eliminating of this study in the endocrine outpatient and inpatient wards of hospital.This study investigated include general epidemiological survey and body constitution investigations and related laboratory tests (thyroid function and it’s antibodies, liver function, blood routine tests)results(The data are from the clinical laboratory of Dongfang Hospital of Beijing University of Chinese Medicine).TCM constitution adopted criteria"Chinese constitution classification and decision tables". Sample sizes according to the coefficient of variation and confidence interval estimated.With Epidate,Excel and other software to establish a database,this study summarized survey data of FT3,FT4 normal CLT patients.SPSS 21.0 software package was used for general statistical methods,including descriptive statistics,nonparametric test,chi-square test,data mining including cluster analysis,regression analysis.All statistical data were tested by two-sided test.When P value is less than 0.05 for the test index,the result has statistical significance.Measurement data are described in this way that mean add and subtract standard deviation.Research production(1)In this survey,the female with CLT were significantly more than the male,and the male to female ratio was 1:6.85.The age of onset was mainly in 20-39 years old and 50-59 years old.The course of disease was mainly located in 1-60 months.CLT patients with normal thyroid function as the main.(2)In this survey,there are 15 cases of simple constitution including 12 cases of ideal body constitution,l cases of Qi deficiency,1 cases of Qi stagnation,and 1 cases of Yin deficiency in all CLT patients.And 87 cases of mingled body constitution,often mixed 2-5 kind of body constitution.In the survey,the 9 kinds of constitution distribution frequency of 102 patients with FT3,FT4 normal CLT reach to 324 times,including 31 cases of ideal body constitution,63 cases of Qi asthenia constitution,52 cases of Qi stagnation constitution,48 cases of Yang deficiency constitution,39 cases of Phlegm-dampness constitution,35 cases of Yin deficiency constitution,29 cases of Dampness-heat constitution,22 cases of Blood stasis constitution,5 cases of Special intrinsic constitution.(3)In the investigation,constitution frequency distribution of 102 CLT patients analysized by hierarchical cluster,with binary Euclidean distance metric to cluster analysis.The result is that:Qi asthenia constitution,Qi stagnation constitution,often each other blended,Qi asthenia constitution,Yang deficiency constitution,often each other blended,Yin deficiency,Phlegm-dampness and dampness-heat constitution often mixed,Blood stasis and Yin deficiency often mixed,Ideal body constitution is often a simple constitution.(4)The nine kinds of body constitution were set to the dependent variable,and FT3, FT4,TSH,thyroid specific antibody,age stratified were set to covariate and in the way of backward stepwise method (likelihood ratio statistic) were factors binary Logistic regression analysis.When the dependent variable is Yang deficiency constitution,TPOAb stratification,TGAb stratificationage as a factor entered the regression equation.TPOAb stratification,TGAb stratificationage correlated with Yang deficiency constitution were positively.The higher TPOAb stratification,TGAb stratificationage,the greater the possibility of Yang deficiency constitution.The rest of the body into the regression equation of the factors did not find statistical significance.ResultThe main kind of body constitution of patients with FT3,FT4 normal CLT is mixed constitution,and its distribution frequencies were significantly higher than that of simple constitution. And the main kinds of blended constitution are Qi asthenia,Qi stagnation,Yang deficiency,moreover the three easily mixed with each other.In addition to the blended body constitution were Qi asthenia constitution and Qi stagnation constitution,Qi asthenia constitution and Yang deficiency constitution, Yin deficiency,Phlegm-dampness and Dampness-heat constitution,Blood stasis and Yin deficiency.This suggests that the common physical types of chronic lymphocytic thyroiditis is Qi asthenia,Qi stagnation and deficiency of Yang and may cause Qi stagnation resulted in Qi asthenia,Yang deficiency and the pathological product accumulation,syndrome of deficiency of fluid,Phlegm-dampness,Dampness-heat,Blood stasis and Yin deficiency,leading to the progression of the disease and deteriorationTPOAb,TGAb titer Stratification and Yang and quality-related,TPOAb,TGAb stratified higher,the greater the likelihood of Yang deficiency.Timely adjustment of Yang deficiency and other biased constitution for improving quality and TGAb TPOAb titer levels may help,but it need further research confirms.