Study On Infrared And Raman Spectra Of Sinomenine And Sinomenine Hydrochloride

Sinomenine (SM) is a kind of famous biological medical material in the world, which can be extracted from the traditional Chinese medicine-the sabiifolia. It is an alkaloid monomer and has a certain chemical structure (C19H23NO4). The study on the medical application of its functional groups has become very important. In the meantime, as a hydrochloride of the SM, the sinomenine hydrochloride (SMHC1, C19H24NO4CI) possesses a better water-solubility than the SM and therefore is used more widely and directly.It is well known that many measurement methods, such as the X-ray electronic energy spectrum, X-ray diffraction and neutron elastic scattering ones, are usually used to determine the molecular structures and ingredients of the studied matter, but have their respective disadvantages. Infrared (IR) spectroscopy and Raman spectroscopy are two of the important supporting methods for those targets. Whereas in general, the IR spectra have low resolution ratio, and the Raman spectra are not frequently studied because of the expensive measurement devices.This master’s thesis will describe the following work:1. IR and Raman spectra with high resolution ratios of the SM and the SMHC1 with high purity are measured, respectively, as can be seen in Chapters 2 and 3.2. Longitudinally comparative analysis on the IR spectra (in Chapter 2) and Raman (in Chapter 3) of the SM and the SMHC1 are performed, respectively. Through these studies, commonly possessed spectral lines with nearly same data (at the assumption that the wavenumber difference Av is in the range of ±10 cm=1, in the IR spectral region of 400-4000 cm-1, the SM and the SMHC1 have 48 common possessed IR spectral lines, as described in Chapter 2, and in the Raman spectral region of 50-4000 cm-1,56 common possessed Raman spectral lines, as described in Chapter 3) and their corresponding typical spectral data (in the IR spectral region, the SM and the SMHC1 have 2 and 7 typical IR spectral lines, respectively, whereas in the Raman spectral region, they have 9 and 4 typical Raman spectral lines, respectively) are found out to benefit making a distinction between them.3. Laterally comparative analysis on the IR-Raman spectra of the SM (in Chapter 4) and the SMHC1 (in Chapter 5) are conducted, respectively. Through these studies, both active (both IR and Raman active) spectral lines with nearly same data (at the assumption that the wavenumber difference Av is in the range of ±10 cm-1, in the IR spectral region, the SM has 43 both active spectral lines, as described in Chapter 4, and the SMHCI has 41 both active spectral lines, as described in Chapter 5) and their corresponding typically active (either IR or Raman active) spectral data (in the IR spectral region, the SM and the SMHCI have 11 and 22 typically IR active spectral lines, respectively, whereas they have 14 and 19 typically Raman active spectral lines, respectively) are found out to further help make a distinction between them.In a word, this thesis gives out the most detail, to the best of our knowledge, IR and Raman spectral data, although they can be completely assigned correctly to the particular functional groups till now. I hope that the completely correct assignment can be done after the experiment and analysis of their deuterized samples, which will be performed in the near future.