| Objective:The characteristics of medical records of patients with PCOS were collected. On the one hand analysis of differences between elements of TCM syndromes in obese and non obese patients and to explore the syndrome differentiation and treatment; on the other hand, relatively simple traditional Chinese medicine and traditional Chinese medicine combined with the two groups of PCOS patients curative effect on the treatment of.Method:In this trial, the group control method will be used to meet the PCOS diagnosis, and the patients in the test standard are included in the group. Patients with BMI>28kg/m2 were included in the obese group, and the patients with BMI<28kg/m2 were included in the non obese group. Non obese group received conventional Chinese medicine treatment, obesity group on the basis of traditional Chinese medicine treatment to be given metformin tablets 3/0.5g oral, test cycle for 3 months. The patients in the group were based on the syndrome differentiation and syndrome differentiation of syndrome differentiation made by Professor Zhu Wenfeng. At the same time, the height, weight, body mass index, menstruation status, sex hormone level and so on were recorded. After 3 months, the indexes were reviewed, the difference before and after the index and the changes of menstruation. The two groups of patients were compared before and after treatment in the group, but also to compare the efficacy between the two groups.Result:At first,52 patients were enrolled in the trial, including 22 obese group and 30 non obese group.3 months after the end of the test cycle, the obese group of 18 people,25 people in non obese group, a total of 43 people. Obese group and non obese group of patients with menopausal status were mainly manifested as oligomenorrhea or amenorrhea, the normal menstrual or menstrual dripping wet endless accounts for a relatively small proportion. The sex hormone levels in the two groups before treatment were compared, and the LH and LH/FSH in the obese group were lower than that in the non obese group (P<0.05). There were significant differences between the two groups. The obese group and non obese group in the syndrome elements of the "liver" and "kidney" have significant difference (P<0.05), the obese group of syndrome element "kidney" obvious more than non obese group and non obese group, the disease syndrome elements of the "liver" significantly more than the obese group. There was no significant difference in syndrome elements "heart" and "spleen" (P> 0.05). The obese group and non obese group in nature syndrome elements, "phlegm", "qi stagnation", "Yin" and "Yang" had significant difference (P<0.05), which in the obese group in the disease syndrome element "phlegm", "Yang" significantly more than non obese group; and non obesity group "stagnation", "Yin Deficiency" of the disease syndrome element significantly more than the obese group. The two in the "hot", "blood" and "Qi", "blood deficiency" of the disease syndrome elements, no significant differences (P<0.05). The pure traditional Chinese medicine and traditional Chinese medicine combined with metformin treatment can improve patients with menstrual disorders, both no statistical difference (P> 0.05). The Chinese medicine group and traditional Chinese medicine combined with metformin can reduce the LH, LH/FSH, T, BMI. Among the obese group, the above indexes were significantly lower than those before treatment, and there were significant differences (P <0.05). Seventhly, in 3 months trial period obese group 1 cases had abdominal distension and metformin for metformin enteric coated tablets after abdominal distension significantly improved. Non obesity group had 2 patients complained of diarrhea and mild nausea. After prescription of traditional Chinese medicine adjust and correct the bad drug habit is to be recovered.3 cases of patients in the late observation did not tell any discomfort. There were no obvious adverse drug reactions in the two groups during the experiment.Conclusion:At first,52 patients were enrolled in the trial, including 22 obese group and 30 non obese group.3 months after the end of the test cycle, the obese group of 18 people,25 people in non obese group, a total of 43 people. Obese group and non obese group of patients with menopausal status were mainly manifested as oligomenorrhea or amenorrhea, the normal menstrual or menstrual dripping wet endless accounts for a relatively small proportion. The sex hormone levels in the two groups before treatment were compared, and the LH and LH/FSH in the obese group were lower than that in the non obese group (P<0.05). There were significant differences between the two groups. The obese group and non obese group in the syndrome elements of the "liver" and "kidney" have significant difference (P<0.05), the obese group of syndrome element "kidney" obvious more than non obese group and non obese group, the disease syndrome elements of the "liver" significantly more than the obese group. There was no significant difference in syndrome elements "heart" and "spleen" (P> 0.05). The obese group and non obese group in nature syndrome elements, "phlegm", "qi stagnation", "Yin" and "Yang" had significant difference (P<0.05), which in the obese group in the disease syndrome element "phlegm", "Yang" significantly more than non obese group; and non obesity group "stagnation", "Yin Deficiency" of the disease syndrome element significantly more than the obese group. The two in the "hot", "blood" and "Qi", "blood deficiency" of the disease syndrome elements, no significant differences (P<0.05). The pure traditional Chinese medicine and traditional Chinese medicine combined with metformin treatment can improve patients with menstrual disorders, both no statistical difference (P> 0.05). The Chinese medicine group and traditional Chinese medicine combined with metformin can reduce the LH, LH/FSH, T, BMI. Among the obese group, the above indexes were significantly lower than those before treatment, and there were significant differences (P <0.05). Seventhly, in 3 months trial period obese group 1 cases had abdominal distension and metformin for metformin enteric coated tablets after abdominal distension significantly improved. Non obesity group had 2 patients complained of diarrhea and mild nausea. After prescription of traditional Chinese medicine adjust and correct the bad drug habit is to be recovered.3 cases of patients in the late observation did not tell any discomfort.There were no obvious adverse drug reactions in the two groups during the experiment. |
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