Study On Molecular Mechanism Of Obesity Prevention And Treatment By Exercises

With the development of society and the increasing living standard, the incidence of obesity is increasing year by year, which has been a serious human health problem in the world. Obesity prevention and treatment has been a principal task to improve human health. As a method to treat obesity, aerobic exercise has been accepted extensively. With the extension of scientific research methods, it suggests that UCP3 of skeletal muscle is likely to one of the most important factors to affect energy consume during exercise and resting metabolic rate after exercise.The purpose of this experiment is to observe the influence of different acute aerobic exercises on UCP3mRNA expression level of SD male rat and analyze internal relation between UCP;imRNA expression level and content of serum FFA and serum Leptin. This research provide theoretical basement to scientifically select pattern, intension, duration, interval, frequency of exercises, and make, reasonable exercise prescription.The results show that (1) acute aerobic exercise can treat obesity by up-regulate UCPjnRNA expression; (2) different acute aerobic exercises have different effects on UCP3mRNA expression, swimming exercise can up-regulate UCP3mRNA expression more than treadmill running, this maybe relevant to special environment of swimming exercise. Additionally it may be different from treadmill exercise in intension and stimulation ; (3) Acute aerobic exercises have periodic effect on muscle UCPjmRNA expression, which is affected by many factors including exercise pattern, intention, fast, serum FFA, hormone level.