The Correlation Between Serum Adiponectin, Ghrelin Levels And Metabolic Syndrome

Objective: To compare the levels of serum adiponectin and ghrelin between patients with metabolic syndrome(MS) and control, and their correlations with anthropometric, physiological and blood parameters; quantitatively evaluate the risk of MS in different level of serum adi-ponectin and ghrelin and explore the possibility to predicting the MS with adiponectin and/or ghrelin.Methods:933 teachers in a university were recruited as subjects. Such anthropometric para- meters as height, weight, waist circumference, hip circumference, and blood pressure were mea- sured. Fasting blood sugar, total Cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-c), low density lipoprotein cholesterol (LDL-c) were determined. Serum adi-ponectin, ghrelin of MS patients (N=78; Male: 41; Female:37; Age: 56.88±11.48 years) and normal subjects(N=49; Male:29;Female:27; Age: 53.28±10.72 years) were assessed.Results: (1) The serum adiponectin and ghrelin levels of MS patients were lower signifi-cantly than normal subjects (P<0.05).(2)There was significantly positive correlation between adiponectin and ghrelin (r=0.860, P<0.001).(3)The adiponectin was positively correlated with HDL-c(r=0.267,P=0.005), and negatively correlated with BMI(r=-0.614,P<0.001), WC(r=-0.569,P<0.001), WHR(r=-0.444,P<0.001), FBS(r=-0.221,P=0.022), SBP(r=-0.299, P<0.001), DBP(r=-0.281, P= 0.003), TG(r=-0.286,P= 0.003), LDL-c(r=-0.268,P=0.002). After multiple regression analysis, BMI and WC were the most important variable in predicting adiponectin levels: y=6.844-0.101×BMI-0.02×WC (R2=0.43,P<0.01)(4)The ghrelin was negatively correlated with BMI(r=-0.531,P= 0.000), WC(r=-0.514, P<0.001), WHR(r=-0.427,P=0.00), SBP(r=-0.284, P=0.003), DBP(r=-0.244,P=0.011), TG(r= -0.206,P=0.033), LDL-c(r=-0.251,P= 0.009). After multiple regression analysis, BMI was the independent variable in predicting adiponectin levels: y= -0.086×BMI+2.149 (R2=0.363,P<0.01)(5)Subjects in the lowest adiponectin, ghrelin quartile had a significantly higher probability of having MS. adiponectinQ1: OR=2,P=0.001.ghrelinQ2: OR=2.1,P=0.001.Conclusions:(1) Serum adiponectin, ghrelin levels in MS subjects are significantly lower than that in controls. (2)There are significant correlations among adiponectin, ghrelin and the components of MS. BMI and WC are most important factors of serum adiponectin level, and BMI is the determintive variable in predicting ghrelin level.(3)There is significantly positive correlation between adiponectin and ghrelin. With the de-creasing of serum adiponectin, ghrelin levels, MS prevalence increased.(4)Levels of adiponectin and ghrelin may be sensitive indicators to predict MS, and provide an effective way to diagnosis and treat MS.