Diagnosis, Treatment And Protection Of Early Deep Fungal Infection After Liver Transplantation

Objective To investigate the early diagnosis, treatment protocols and protective measure of early deep fungal infection after liver transplantation.Methods Clinical data of 17 Of 96 patients undergoing liver transplantation with early deep fungal infection from were retrospectively analyzed from June 2001 to March 2010 in Chongqing Organ Transplantation Center,First Affiliated Hospital of Chongqing Medical University . The predisposing factors, etiological characteristics,diagnostic methods,treatment protocols and preventive measures were analyzed.Results Twenty-four case-times of deep fungal infection were diagnosed in 17 cases,and 4 died.Infection rate was 17.7% (17/96),and mortality was 23.5% (4/17).Sixteen case-times of pulmonary infection,6 case-times of intestinal infection,1 case-times of infection of biliary tract and 1 case-times of intracranial infection occurred,of which Candida albicans accounted for 66.67%,non Candida albicans for 16.67%,Aspergillus for 12.50%,and Cryptococcus for 4.17%.Onset time was 5 to 26 days after liver transpltantation.Conclusion Early deep fungal infection is one of important causes influencing survival rate after liver transplantation. Effective prevention , early diagnosis and active treatment are key point of increasing recovery rate of deep fungal infection.