Evaluation Of Threshold For Prophylactic Platelet Transfusions In Patients With Pediatrics Thrombocytopenia

Objective: To evaluate the threshold for prophylactic platelet transfusions in patients with non--immune thrombopenia of childhood. To observe that if the transfusion of 10×10~9 /L of the control group is safe and effient to guand against hemorrhage and hemostasis to the original transfusion of 20×10~9/L . Methods:We evaluated during the period of December, 2008-March, 2010 in our division , in the early blood routine test of non--immune thrombocytopenia childhood patients. The patients who need prophylactic platelet transfusions was divided into two groups, group A was control group (the control arm in which the subjects were given platelets if the morning platelet count was less than 20×10~9/L or if bleeding) , and the group B was observation group (which included subjects who received platelet if the morning count of platelet was lower than 10×10~9/L), compare the frequency and quantity of the platelet transfusions,sexes,nationality,the type of sickness,bleeding situation,the improvement and control of clinical bleeding symptom,and the rates of adverse reactions of platelet transfusions. Results:First, the two groups had no distinct differences in the sexes,nationality,the type of sickness ,and the quantity,the frequency of platelet transfusions, too. Second, the light bleeding events were significantly different between group A and group B, the severe bleeding events were not significantly different between group A and group B, and the clinical bleeding symptom had been effectively controlled and improved. Third, the rates of adverse reactions of platelet transfusions were not significantly different between group A and group B. Conclusion:The childhood patients of group A and group B who under no invasive procedures by a 10×10~9 /L prophylactic platelet transfusion is safe.