The Relationship Of Plasma Homocysteine, Mild Cognitive Impairment And Alzheimer's Disease In Chenzhou

Objective To explore the relationship of homocysteine, mild cognitive impairment and Alzheimer's disease in chenzhou, and find potential laboratorial evidence for discriminating between mild cognitive impairment and Alzheimer's disease in earlier period.Methods The trial based on case control study. Collected patients with mild cognitive impairment or Alzheimer's disease in Chenzhou from September 2007 to September 2009. They were classified into mild cognitive impairment group (group A) and Alzheimer's disease group(group B). Homochronous volunteers in the same city were taken as member of control group(group C). The concentration of plasma homocysteine(Hcy), serum folic acid and vitamin B12, blood glucose and fat were measured for statistical analysis by SPSS13.0.Results (1) The mean plasma Hcy concentration in group A, B and C were 15.11±2.29umol/L, 17.87±4.05umol/L and 10.02±1.92umol/L respectively. In group A, B and C, 47.27%, 75.47%, 2% patients had HHcy respectively. The deviations of plasma Hcy concentration and HHcy frequency rate were significant among group A, B and C(P<0.05). (2) In group A, B and C, the serum folic acid concentration were 5.98±1.16ng/mL, 5.08±1.35ng/mL and 7.82±0.77ng/mL, and the serum vitamin B12 were 330.36±55.02pg/mL, 267.78±82.86 pg/mL and 661.54±97.88 pg/mL, respectively. The deviations of serum folic acid and vitamin B12 concentration were significant among the three groups (P<0.05). (3) According to Spearman correlative analysis method, the concentration of the plasma Hcy had a negative correlation with those of serum folic acid and vitamin B12 (P<0.01). And, blood glucose concentration had a positive correlation with the plasma Hcy concentration (P<0.01). (4) Based on binary logistic regression, it was manifested that HHcy was an independent risk factor of mild cognitive impairment and Alzheimer's disease. The odd ratios (OR) of HHcy was 27.394 (95%CI 4.192 to 179.007). Conclusions HHcy maybe an independent risk factor of mild cognitive impairment and Alzheimer's disease in chenzhou.