| ObjectiveObserve the effects of traditional Chinese medicine rectal instillation therapy combined western medicine that treat cholestatic Infancy hepatitis syndrome, and the influence of right jaundice cases, laboratory testing indicators (liver function, etc.); TCM rectal instillation and oral drug therapy with traditional Chinese medicine, Western medicine therapy alone to comparison. Discussion the efficacy and mechanism of TCM rectal instillation therapy, action for the clinical application to provide theoretical basis with relevant and reliable.MethodsSelect the Integrated Chinese and Western medicine wards an d Western medicine of Gastroenterology wards from August 2008 t o October 2009 in line with hospital treatment of cholestatic i nfancy hepatitis syndrome diagnosis of 45 cases, which 25 cases were male infants and 20 cases were female infants. Using rand omized grouping, all cases were divided into three groups:the test group 15 cases, the first control group 15 cases, the seco nd control group 15 cases. The test group use TCM rectal instil lation combined western medicine therapy, the first control gro up use oral drug therapy with TCM combined western medicine the rapy, the second group use western medicine therapy.2 weeks fo r a course of treatment, after three treatments, by observing o f serum totalbilirubin(TBIL), direct bilirubin(DBIL), alanine ami notransferase (ALT), alkaline phosphayase (ALP), total bile acid(TB A),γ-glutamyI GGT(γ-GT), prothrombin time(PT), CMV-IgM negative conversion rate and liver size (cm) of three groups before and after treatment, using analysis of variance, t test, binomial d istribution and other statistical methods to determine whether statistically have significance difference.Results1 After treatment, TBIL, DBIL, ALP, ALT, TBA, y-GT and liver size(cm) values of three groups had lower than those before treatment, compared before and after treatment there was a significant difference (P<0.01).2 After treatment, TBIL, DBIL, TBA values of the test group compared with of the control first group, which had a significant difference (P<0.05), the test group compared with the control second group, which had a significant difference (P<0.05); after treatmentγ-GT value of three groups, the test group compared with the control first group, which had a significant difference (P<0.05), the test group compared with the control second group, there had a significant difference (P<0.01); after treatment, ALT, ALP and liver size of three groups, the test group compared with the control first group, which had no significant difference (P>0.05), the test group and control second group, there had a significant difference (P<0.01).3 After treatment, PT values of three groups had lower than before treatment, by comparison there had a significant difference (P<0.01), the test group compared with the control first group, which had no significant difference (P>0.05), the test group compared with the control second group, there had no significantly different (P>0.05).4 Comparison of CMV-IgM negative rate of three groups after treatment, the test group compared with the control first group, which had no significant difference (P>0.05), the test group compared with the control second group, there was significantly different (P<0.05).5 Comparison of total effective rate of three groups after treatment, the test group cured 5 cases, accounting for 33.33%, improved in 9 cases, accounting for 60.00%, healed in one cases, accounting for 6.67%, total effective 14 cases, accounting for 93.33%; the control first group cured 3 cases, accounting for 20.00%, improved in 10 cases, accounting for 66.67%, healed in 2 cases, accounting for 13.33%, total effective 13 cases, accounting for 86.67%; the control second group cured 2 cases, accounting for 13.33%, improved in 8 cases, accounted for 53.33%, healed in 5 cases, accounting for 33.33%, total effective 10 cases, accounting for 66.67%. The total efficiency of the test group compared with the control first group, which had no significant difference (P>0.05), compared with the control second group, there was significant difference in contrast (P<0.05).conclusion1 By cholestatic infant hepatitis syndrome with traditional Chinese medicine rectal instillation combined western medicine before and after the total effective observation, and the use of statistical methods for analysis and comparison, it Confirmed that traditional Chinese medicine rectal instillation combined western medicine therapy is better than simply using western medicine, and the same to oral drug therapy with TCM combined Western2 TBIL, DBIL, ALP, ALT, TBA,γ-GT, PT, CMV-IgM negative conversion rate and liver size (cm) values of three groups after treatment had lower than those before treatment, and through statistical methods for analysis and comparison, shows the effectiveness of treatment.3 By observations the statistical results of ALP, ALT, CMV-IgM negative conversion rate and liver size (cm), it can be drawn from TCM rectal instillation combined western medicine is better than western medicine and oral drug with TCM combined western medicine considerable;by observation the statistical result of PT, it can be drawn from TCM rectal instillation combined western medicine is the same as western medicine and oral drug with TCM combined western medicine; and after treatment by observing the statistical results of TBIL, DBIL, TBA,γ-GT value, we can see TCM combined western medicine rectal instillation therapy was superior to oral drug with TCM therapy and simple Western medicine therapy, indicating rectal instillation therapy in reducing TBIL, DBIL, TBA,γ-GT value has its advantages, and this therapy safe and convenient, with a high degree of children with no obvious side effects, suitable for the clinic.
|
PDF Full Text Request