| Objective: By enzyme-linked immunosorbent assay(Enzyme-linked immunosorbent assay, ELISA) method, Mycoplasma pneumoniae (Mycopl- asma pneumoniae, Mp)IgG, IgM antibodies in human serum were measured to explore the relationship between the Mycoplasma pneumoniae infection and the occurrence of cerebral infarction, and whether the Mycoplasma pneumoniae infection was an independent risk factors in the occurrence and development of cerebral infarction in a preliminary study.Methods: 1 The Subjects were from the neurology department inpatients of the Second hospital of Hebei Medical University and the healthy people for physical examination in the hospital, during January 2009 to September 2009. They were divided into three groups: the first group(referred to as non-risk group)30 patients of CI without any dangerous (14 male and 16 female) the mean age was 56.34±6.34 years old (rang from 27 ~ 69 years old). The clinical and imaging study of patients diagnosed as cerebral infarction, who were confirmed by MRA without vascular malformation, not smoking, not drinking alcohol or less, without hypertension, no hyperlipidemia and without diabetes, blood diseases side by side and apart from atrial fibrillation caused by brain embolism, non-immune deficiency diseases and autoimmune diseases, no heart, liver, renal dysfunction and no apparent genetic predisposition of familial cases, non-hereditary spherical cell histiocytosis; the second group(referred to as high-risk group) 30 patients of CI with one or several dangerous (15 male and 15 female) the mean age was 58.36±5.28 years old(rang from 33 ~ 68 years old), all the diagnostics consist with the criteria of cerebral infarction in the Fourth National Cerebrovascular Disease Conference in 1995 and the meeting of international cerebral vessels in 2008 ,and they were all confirmed by brain CT or MRI, except for transient ischemic attack, reversible cerebral infarction, etc; the third group(referred to as the control group) 30 patients of CI without any dangerous (14 male and 16 female) the mean age was 54.43±5.25 years (rang from 32 ~ 68 years old).This group had not found lesions by carotid artery ultrasound, head CT or MRI examination, who were non-smoking, drinking, no hypertension, no diabetes, no hyperlipidemia and no signs of the nervous system with positioning(short-listed conditions the age of the three group were similar, and difference between the age and the sex had no statistic meaning). After all the study patients had fasted 10 hours or more, the next morning drew peripheral venous blood 3ml, placed in -70℃freezer until ELISA. 2 The results would be dealt with SPSS 16.0 statistical software: measurement data were tesetd by t test, enumeration data by Chi-square test, size of t test and Chi-square test"a"equal to 0.05, compare with each other the statistic"α′"equal to 0.0125.Results: Using ELISA method, there were 9 people who infected Mycoplasma pneumoniae in the non-risk disease group(6 people had IgG antibodies,3 people had IgM antibodies), the positive rate was 30%; in the high-risk disease group there were 1 people infected Mycoplasma pneumoniae,who had IgM antibodies, the positive rate was 3.3%; however, there were 6 people in the control group, the positive rate was 20%, According statistical analysis we concluded that there was significant different between the three group ( X2=7.449,P=0.024). Compared to each two of them, we drew a conclusion it was different between non-risk group and the high-risk group ( X2=7.680, P =0.006), there was no statistical difference between non-risk group and contral group (X2=0.800,P=0.371), high-risk group and the control group(X2=2.588, P=0.108).Conclusion: Mycoplasma pneumoniae infection was associated with the occurrence of cerebral infarction, Maybe serve as an independent risk factor for cerebral infarction.
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