Observation Of KuiJieYiHao Prescription Combined With Chinese Medical Colonic Cleansing Treating Ulcerative Colitis And Mechanism Research Of NF-κB And TNF-α

Objective The purpose of this reseach is to observe the clinical effect of KuiJieYiHao prescription Combined With Chinese Medical Colonic Cleansing Releasing ulcerative colitis; determinate the expression of NF-κB and TNF-αin colonic tissue of the patient, and to explore the possible action mechanism of UC.Methods Forty patients who were diagnosed as in active stage of UC by colonpscopy and diagnosed as the syndrome of internal stasis of dampness and heat by syndrome differentiation of traditional Chinese medicine were divided into two groups. in treatment group,20 patients were treated with taking KuiJieYiHao prescription in combination with retention with enema prescription in activity period; while the other 20 patients in the control group were treated with particle release mesalazine. When the treatment is over, compare the clinical curative effect,the states of the intestinal mucous membrane and the remission rate. Then test the expression of NF-κB and TNF-αin colonic tissue of the patient with the Immunohistochemistry method.Results The effect of improving symptoms of diarrhea, mucous bloody stool, abdominal pain in treatment group was better than that in control group (P<0.05), There was statistical difference between the total effective rate of the two groups, and the curative effect in treatment group was better than that in control group (P<0.05). The effect of improving the lesions of colonic mucosa in treatment group was better than that in control group (P<0.05). The effect of improving the remission rate in treatment group was better than that in control group (P<0.05).The effect of inhibition of the explaination of the NF-κB and TNF-αin colonic tissue of the patient in treatment group was better than that in control group (P<0.05).Conclusion The curative effect of KuiJieYiHao Prescription Combined With Chinese Medical Colonic Cleansing treating ulcerative colitis patients is better than that of 5-ASA.The main mechanism may be restraining the expression of NF-κB and TNF-α.